Biomaterials for bone tissue engineering

被引:892
作者
Stevens, Molly M. [1 ,2 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Dept Mat, London SW7 2AZ, England
[2] Univ London Imperial Coll Sci Technol & Med, Inst Biomed Engn, London SW7 2AZ, England
关键词
D O I
10.1016/S1369-7021(08)70086-5
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Materials that enhance bone regeneration have a wealth of potential clinical applications from the treatment of nonunion fractures to spinal fusion. The use of porous material scaffolds from bioceram c and polymer components to support bone cell and tissue growth is a longstanding area of interest. Current challenges include the engineering of materials that can match both the mechanical and biological context of read bone tissue matrix and support the vascularization of large tissue constructs. Scaffolds with new levels of biofunctionality that attempt to recreate nanoscale topographical and biofactor cues from the extracellular environment are emerging as interesting candidate biomimetic materials.
引用
收藏
页码:18 / 25
页数:8
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