Akt-mediated phsophorylationof EZH2 suppresses methylation of lysine 27 in histone H3

被引：453
作者：
Cha, TL
Zhou, BHP
Xia, WY
Wu, YD
Yang, CC
Chen, CT
Ping, B
Otte, AP
Hung, MC
机构：
[1] Univ Texas, MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA
[2] Univ Texas, Hlth Sci Ctr, Grad Sch Biomed Sci, Houston, TX 77030 USA
[3] Univ Amsterdam, Swammerdam Inst Life Sci, NL-1098 SM Amsterdam, Netherlands
来源：
SCIENCE | 2005年 / 310卷 / 5746期
关键词：
D O I：
10.1126/science.1118947
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Enhancer of Zeste homolog 2 (EZH2) is a methyltransferase that plays an important role in many biological processes through its ability to trimethylate lysine 27 in histone H3. Here, we show that Akt phosphorylates EZH2 at serine 21 and suppresses its methyltransferase activity by impeding EZH2 binding to histone H3, which results in a decrease of lysine 27 trimethylation and derepression of silenced genes. Our results imply that Akt regulates the methylation activity, through phosphorylation of EZH2, which may contribute to oncogenesis.
引用
收藏
页码：306 / 310
页数：5
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