AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides

被引：33
作者：
Acevedo-Jake, Amanda [1 ]
Ball, Andrew T. [1 ]
Galli, Marzia [1 ]
Kukwikila, Mikiembo [1 ]
Denis, Mathieu [1 ]
Singleton, Daniel G. [2 ]
Tavassoli, Ali [1 ]
Goldup, Stephen M. [1 ]
机构：
[1] Univ Southampton, Chem, Southampton SO17 1BJ, Hants, England
[2] Univ Southampton, Sch Chem, ATDBio Ltd, Southampton SO17 1BJ, Hants, England
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2020年 / 142卷 / 13期
基金：
英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会; 欧洲研究理事会;
关键词：
ARTIFICIAL MOLECULAR MACHINES; LASSO PEPTIDES; DRUG-DELIVERY; DNA; GENE; ROTAXANES; CATENANES; NANOSTRUCTURES; POLYROTAXANES; MACROCYCLE;
D O I：
10.1021/jacs.0c01670
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties.
引用
收藏
页码：5985 / 5990
页数：6
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