Sulfation Pattern Dependent Iron(III) Mediated Interleukin-8 Glycan Binding

被引：6

作者：

Brunori, Francesco ^{[1
,2
,3
]}

Padhi, Deepak Kumar ^{[1
,2
]}

Alshanski, Israel ^{[1
,2
]}

Freyse, Joanna ^{[4
]}

Duerig, Jan-Niklas ^{[4
]}

Penk, Anja ^{[5
]}

Vaccaro, Luigi ^{[3
]}

Hurevich, Mattan ^{[1
,2
]}

Rademann, Joerg ^{[4
]}

Yitzchaik, Shlomo ^{[1
,2
]}

机构：

[1] Hebrew Univ Jerusalem, Inst Chem, Safra Campus, IL-91904 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Ctr Nanosci & Nanotechnol, Safra Campus, IL-91904 Jerusalem, Israel

[3] Univ Perugia, Lab Green Synthet Organ Chem, Dipartimento Chim Biol Biotecnol, Via Elce di Sotto 8, I-06123 Perugia, Italy

[4] Free Univ Berlin, Med Chem, Konigin Luise Str 2 4, D-14195 Berlin, Germany

[5] Univ Leipzig, Med Fac, Inst Med Phys & Biophys, Hartelstr 16-18, D-04107 Leipzig, Germany

来源：

CHEMBIOCHEM | 2022年 / 23卷 / 03期

关键词：

electrochemistry; interactions; interleukin-8; metal binding; sulfation pattern; HYALURONIC-ACID; EXTRACELLULAR-MATRIX; COLLAGEN I; METAL-IONS; GLYCOSAMINOGLYCANS; HYDROGEL; CELLS;

D O I：

10.1002/cbic.202100552

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytokines such as interleukin-8 activate the immune system during infection and interact with sulfated glycosaminoglycans with specific sulfation patterns. In some cases, these interactions are mediated by metal ion binding which can be used to tune surface-based glycan-protein interactions. We evaluated the effect of both hyaluronan sulfation degree and Fe3+ on interleukin-8 binding by electrochemical impedance spectroscopy and surface characterizations. Our results show that sulfation degree and metal ion interactions have a synergistic effect in tuning the electrochemical response of the glycated surfaces to the cytokine.

引用

页数：6

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