Severe Achromobacter xylosoxidans infection and loss of sputum bacterial diversity in an adult patient with cystic fibrosis

被引：10

作者：

Talbot, Nick P. ^{[1
,2
]}

Flight, William G. ^{[1
]}

机构：

[1] Oxford Univ Hosp NHS Fdn Trust, Oxford Adult Cyst Fibrosis Ctr, Oxford, England

[2] Univ Oxford, Nuffield Dept Med, Oxford OX1 2JD, England

来源：

PAEDIATRIC RESPIRATORY REVIEWS | 2016年 / 20卷

关键词：

Cystic fibrosis; Achromobacter xylosoxidans; Sputum microbiome; Cross-infection; ALCALIGENES-XYLOSOXIDANS; COLONIZATION; PREVALENCE;

D O I：

10.1016/j.prrv.2016.06.011

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Achromobacter spp. are emerging pathogens in the lungs of patients with cystic fibrosis. We report the case of an adult patient with cystic fibrosis and chronic A. xylosoxidans infection who experienced rapid, progressive clinical deterioration. Metagenomic analysis of the sputum revealed that the airway microbiota was almost entirely dominated by A. xylosoxidans. We review the impact of this organism on lung function and the airway microbiome in cystic fibrosis, and discuss the potential for cross-infection between patients. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：27 / 29

页数：3

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