Recommended Definitions of Aggressive Prostate Cancer for Etiologic Epidemiologic Research

被引：44

作者：

Hurwitz, Lauren M. ^{[1
]}

Agalliu, Ilir ^{[2
]}

Albanes, Demetrius ^{[1
]}

Barry, Kathryn Hughes ^{[3
,4
]}

Berndt, Sonja, I ^{[1
]}

Cai, Qiuyin ^{[5
]}

Chen, Chu ^{[6
]}

Cheng, Iona ^{[7
]}

Genkinger, Jeanine M. ^{[8
]}

Giles, Graham G. ^{[9
,10
,11
]}

Huang, Jiaqi ^{[1
]}

Joshu, Corinne E. ^{[12
]}

Key, Tim J. ^{[13
]}

Knutsen, Synnove ^{[14
]}

Koutros, Stella ^{[1
]}

Langseth, Hilde ^{[15
,16
]}

Li, Sherly X. ^{[9
,10
,17
]}

MacInnis, Robert J. ^{[9
,10
]}

Markt, Sarah C. ^{[18
]}

Penney, Kathryn L. ^{[19
,20
]}

Perez-Cornago, Aurora ^{[13
]}

Rohan, Thomas E. ^{[2
]}

Smith-Warner, Stephanie A. ^{[20
,21
]}

Stampfer, Meir J. ^{[20
]}

Stopsack, Konrad H. ^{[22
]}

Tangen, Catherine M. ^{[23
]}

Travis, Ruth C. ^{[13
]}

Weinstein, Stephanie J. ^{[1
]}

PhD, Wu Lang ^{[24
]}

Jacobs, Eric J. ^{[1
,25
]}

Mucci, Lorelei A. ^{[1
,20
]}

Platz, Elizabeth A. ^{[1
,12
]}

Cook, Michael B. ^{[1
]}

机构：

[1] NCI, Div Canc Epidemiol & Genet, 9609 Med Ctr Dr, Bethesda, MD 20850 USA

[2] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA

[3] Univ Maryland, Sch Med, Dept Epidemiol & Publ Hlth, Baltimore, MD 21201 USA

[4] Univ Maryland, Program Oncol, Marlene & Stewart Greenebaum Comprehens Canc Ctr, Baltimore, MD 21201 USA

[5] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Vanderbilt Epidemiol Ctr,Dept Med,Div Epidemiol, Nashville, TN 37212 USA

[6] Fred Hutchinson Canc Res Ctr, Program Epidemiol, Div Publ Hlth Sci, Seattle, WA 98104 USA

[7] Univ Calif San Francisco, Dept Epidemiol & Biostat, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA USA

[8] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY USA

[9] Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia

[10] Univ Melbourne, Ctr Epidemiol & Biostat, Parkville, Vic, Australia

[11] Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia

[12] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[13] Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England

[14] Loma Linda Univ, Sch Publ Hlth, Loma Linda, CA 92350 USA

[15] Canc Registry Norway, Dept Res, Oslo, Norway

[16] Imperial Coll London, Dept Epidemiol & Biostat, London, England

[17] Univ Cambridge, Med Res Council Epidemiol Unit, Cambridge, England

[18] Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA

[19] Harvard Med Sch, Brigham & Womens Hosp, Channing Div Network Med, Dept Med, Boston, MA 02115 USA

[20] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[21] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA

[22] Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA

[23] Fred Hutchinson Canc Res Ctr, SWOG Stat & Data Management Ctr, 1124 Columbia St, Seattle, WA 98104 USA

[24] Univ Hawaii Manoa, Univ Hawaii, Canc Ctr, Populat Sci Pacific Program,Canc Epidemiol Div, Honolulu, HI 96822 USA

[25] Amer Canc Soc, Behav & Epidemiol Res Grp, Atlanta, GA 30329 USA

来源：

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | 2021年 / 113卷 / 06期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

RISK; MORTALITY; TRENDS;

D O I：

10.1093/jnci/djaa154

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: In the era of widespread prostate-specific antigen testing, it is important to focus etiologic research on the outcome of aggressive prostate cancer, but studies have defined this outcome differently. We aimed to develop an evidence-based consensus definition of aggressive prostate cancer using clinical features at diagnosis for etiologic epidemiologic research. Methods: Among prostate cancer cases diagnosed in 2007 in the National Cancer Institute's Surveillance, Epidemiology, and End Results-18 database with follow-up through 2017, we compared the performance of categorizations of aggressive prostate cancer in discriminating fatal prostate cancer within 10 years of diagnosis, placing the most emphasis on sensitivity and positive predictive value (PPV). Results: In our case population (n = 55 900), 3073 men died of prostate cancer within 10 years. Among 12 definitions that included TNM staging and Gleason score, sensitivities ranged from 0.64 to 0.89 and PPV5 ranged from 0.09 to 0.23. We propose defining aggressive prostate cancer as diagnosis of category T4 or N1 or M1 or Gleason score of 8 or greater prostate cancer, because this definition had one of the higher PPVs (0.23, 95% confidence interval = 0.22 to 0.24) and reasonable sensitivity (0.66, 95% confidence interval = 0.64 to 0.67) for prostate cancer death within 10 years. Results were similar across sensitivity analyses. Conclusions: We recommend that etiologic epidemiologic studies of prostate cancer report results for this definition of aggressive prostate cancer. We also recommend that studies separately report results for advanced category (T4 or N1 or M1), high-grade (Gleason score >= 8), and fatal prostate cancer. Use of this comprehensive set of endpoints will facilitate comparison of results from different studies and help elucidate prostate cancer etiology.

引用

页码：727 / 734

页数：8

共 21 条

[1] Observational studies and the natural history of screen-detected prostate cancer [J].

Albertsen, Peter C. .

CURRENT OPINION IN UROLOGY, 2015, 25 (03) :232-237

[2]

American Cancer Society, 2020, CANC FACTS FIGURES 2

[3] Prostate cancer epidemiology in the United States [J].

Brawley, Otis W. .

WORLD JOURNAL OF UROLOGY, 2012, 30 (02) :195-200

[4] Genomic Markers in Prostate Cancer Decision Making [J].

Cucchiara, Vito ;

Cooperberg, Matthew R. ;

Dall'Era, Marc ;

Lin, Daniel W. ;

Montorsi, Francesco ;

Schalken, Jack A. ;

Evans, Christopher P. .

EUROPEAN UROLOGY, 2018, 73 (04) :572-582

[5] Lead Time and Overdiagnosis in Prostate-Specific Antigen Screening: Importance of Methods and Context [J].

Draisma, Gerrit ;

Etzioni, Ruth ;

Tsodikov, Alex ;

Mariotto, Angela ;

Wever, Elisabeth ;

Gulati, Roman ;

Feuer, Eric ;

de Koning, Harry .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2009, 101 (06) :374-383

[6] Measures of body fatness and height in early and mid-to-late adulthood and prostate cancer: risk and mortality in The Pooling Project of Prospective Studies of Diet and Cancer [J].

Genkinger, J. M. ;

Wu, K. ;

Wang, M. ;

Albanes, D. ;

Black, A. ;

van den Brandt, P. A. ;

Burke, K. A. ;

Cook, M. B. ;

Gapstur, S. M. ;

Giles, G. G. ;

Giovannucci, E. ;

Goodman, G. G. ;

Goodman, P. J. ;

Hakansson, N. ;

Key, T. J. ;

Mannisto, S. ;

Le Marchand, L. ;

Liao, L. M. ;

MacInnis, R. J. ;

Neuhouser, M. L. ;

Platz, E. A. ;

Sawada, N. ;

Schenk, J. M. ;

Stevens, V. L. ;

Travis, R. C. ;

Tsugane, S. ;

Visvanathan, K. ;

Wilkens, L. R. ;

Wolk, A. ;

Smith-Warner, S. A. .

ANNALS OF ONCOLOGY, 2020, 31 (01) :103-114

[7] Risk factors for prostate cancer incidence and progression in the health professionals follow-up study [J].

Giovannucci, Edward ;

Liu, Yan ;

Platz, Elizabeth A. ;

Stampfer, Meir J. ;

Willett, Walter C. .

INTERNATIONAL JOURNAL OF CANCER, 2007, 121 (07) :1571-1578

[8] The high prevalence of undiagnosed prostate cancer at autopsy: implications for epidemiology and treatment of prostate cancer in the Prostate-specific Antigen-era [J].

Jahn, Jaquelyn L. ;

Giovannucci, Edward L. ;

Stampfer, Meir J. .

INTERNATIONAL JOURNAL OF CANCER, 2015, 137 (12) :2795-2802

[9] Appraising causal relationships of dietary, nutritional and physical-activity exposures with overall and aggressive prostate cancer: two-sample Mendelian-randomization study based on 79148 prostate-cancer cases and 61106 controls [J].

Kazmi, Nabila ;

Haycock, Philip ;

Tsilidis, Konstantinos ;

Lynch, Brigid M. ;

Truong, Therese ;

Martin, Richard M. ;

Lewis, Sarah J. .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2020, 49 (02) :587-596

[10] Trends in the Incidence of Fatal Prostate Cancer in the United States by Race [J].

Kelly, Scott P. ;

Rosenberg, Philip S. ;

Anderson, William F. ;

Andreotti, Gabriella ;

Younes, Naji ;

Cleary, Sean D. ;

Cook, Michael B. .

EUROPEAN UROLOGY, 2017, 71 (02) :195-201

← 1 2 3 →