Multidrug resistance reversal agent from Jatropha elliptica

被引:77
作者
Marquez, B
Neuville, L
Moreau, NJ
Genet, JP
dos Santos, AF
de Andrade, MCC
Sant'Ana, AEG
机构
[1] CNRS, UMR 7573, Ecole Natl Super Chim Paris, Lab Synth Select Organ & Prod Nat, F-75231 Paris, France
[2] Univ Fed Alagoas, Dept Quim, CCEN, Alagoas, Brazil
关键词
Jatropha elliptica; Staphylococcus aureus; fluoroquinolone; resistance; Efflux Pump Inhibitor;
D O I
10.1016/j.phytochem.2005.06.008
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
As part of an ongoing project to identify plant natural products as resistance-modifying agents, bioassay-guided fractionation of an extract of Jatropha elliptica (Pohl) Muell Arg. led to the isolation of a penta-substituted pyridine, namely 2,6-dimethyl-4-phenyl-pyridine-3,5-dicarboxylic acid diethyl ester (8). The structure was established by spectroscopic methods. This known compound was assayed for in vitro antibacterial and resistance-modifying activities against strains of Staphylococcus aureus possessing the MsrA and NorA resistance efflux mechanisms. Antibiotic efflux studies indicated that (8) acts as an inhibitor of the NorA efflux pump and restores the level of intracellular drug concentration. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1804 / 1811
页数:8
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