Multidrug resistance reversal agent from Jatropha elliptica

被引：74
作者：
Marquez, B
Neuville, L
Moreau, NJ
Genet, JP
dos Santos, AF
de Andrade, MCC
Sant'Ana, AEG
机构：
[1] CNRS, UMR 7573, Ecole Natl Super Chim Paris, Lab Synth Select Organ & Prod Nat, F-75231 Paris, France
[2] Univ Fed Alagoas, Dept Quim, CCEN, Alagoas, Brazil
来源：
PHYTOCHEMISTRY | 2005年 / 66卷 / 15期
关键词：
Jatropha elliptica; Staphylococcus aureus; fluoroquinolone; resistance; Efflux Pump Inhibitor;
D O I：
10.1016/j.phytochem.2005.06.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
As part of an ongoing project to identify plant natural products as resistance-modifying agents, bioassay-guided fractionation of an extract of Jatropha elliptica (Pohl) Muell Arg. led to the isolation of a penta-substituted pyridine, namely 2,6-dimethyl-4-phenyl-pyridine-3,5-dicarboxylic acid diethyl ester (8). The structure was established by spectroscopic methods. This known compound was assayed for in vitro antibacterial and resistance-modifying activities against strains of Staphylococcus aureus possessing the MsrA and NorA resistance efflux mechanisms. Antibiotic efflux studies indicated that (8) acts as an inhibitor of the NorA efflux pump and restores the level of intracellular drug concentration. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1804 / 1811
页数：8
相关论文
共 58 条
[1]  
[Anonymous], 1987, PHYTOTHER RES, DOI DOI 10.1002/PTR
[2]   POTENTIATION OF SOME ANTICANCER AGENTS BY DIPYRIDAMOLE AGAINST DRUG-SENSITIVE AND DRUG-RESISTANT CANCER CELL-LINES [J].
ASOH, K ;
SABURI, Y ;
SATO, S ;
NOGAE, I ;
KOHNO, K ;
KUWANO, M .
JAPANESE JOURNAL OF CANCER RESEARCH, 1989, 80 (05) :475-481
[3]   Inhibitors of multidrug resistance to antitumor agents (MDR) [J].
Avendaño, C ;
Menéndez, JC .
CURRENT MEDICINAL CHEMISTRY, 2002, 9 (02) :159-193
[4]   Phenolic metabolites of Dalea versicolor that enhance antibiotic activity against model pathogenic bacteria [J].
Belofsky, G ;
Percivill, D ;
Lewis, K ;
Tegos, GP ;
Ekart, J .
JOURNAL OF NATURAL PRODUCTS, 2004, 67 (03) :481-484
[5]   Mobile genes coding for efflux-mediated antimicrobial resistance in Gram-positive and Gram-negative bacteria [J].
Butaye, P ;
Cloeckaert, A ;
Schwarz, S .
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2003, 22 (03) :205-210
[6]   EVIDENCE FOR THE MECHANISM OF THE INHIBITORY-ACTION OF JATROPHONE IN THE ISOLATED RAT UTERINE MUSCLE [J].
CALIXTO, JB ;
SANTANA, AEG .
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM, 1990, 21 (01) :117-122
[7]   Jatrophane diterpenes as modulators of multidrug resistance. Advances of structure-activity relationships and discovery of the potent lead pepluanin A [J].
Corea, G ;
Fattorusso, E ;
Lanzotti, V ;
Motti, R ;
Simon, PN ;
Dumontet, C ;
Di Pietro, A .
JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (04) :988-992
[8]  
Correa M.P., 1984, DICIONARIO PLANTAS U, V3
[9]   Plant products as antimicrobial agents [J].
Cowan, MM .
CLINICAL MICROBIOLOGY REVIEWS, 1999, 12 (04) :564-+
[10]   In vitro activity of older and newer fluoroquinolones against efflux-mediated high-level ciprofloxacin-resistant Streptococcus pneumoniae [J].
Daporta, MT ;
Bellido, JLM ;
Guirao, GY ;
Hernández, MS ;
García-Rodríguez, JA .
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2004, 24 (02) :185-187
123456