Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.

被引：21

作者：

Lu, Shan ^{[1
]}

Nishimura, Shinichi ^{[1
]}

Hirai, Go ^{[2
]}

Ito, Masashi ^{[3
]}

Kawahara, Teppei ^{[4
]}

Izumikawa, Miho ^{[4
]}

Sodeoka, Mikiko ^{[2
]}

Shin-Ya, Kazuo ^{[5
]}

Tsuchida, Toshio ^{[3
]}

Kakeya, Hideaki ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Dept Syst Chemotherapy & Mol Sci, Div Bioinformat & Chem Genom,Sakyo Ku, Kyoto 6068501, Japan

[2] RIKEN, Synthet Organ Chem Lab, Wako, Saitama 3510198, Japan

[3] MicroBioPharm Japan Co Ltd MBJ, Div Res & Dev, Iwata, Shizuoka 4380078, Japan

[4] JBIC, Koto Ku, Tokyo 1350064, Japan

[5] Natl Inst Adv Ind Sci & Technol, Koto Ku, Tokyo 1350064, Japan

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 38期

基金：

日本学术振兴会;

关键词：

BIOSYNTHETIC GENE-CLUSTER; UNIVERSAL NMR DATABASE; STEREOCHEMICAL ASSIGNMENT; ACYCLIC COMPOUNDS; ANTIBIOTICS; CREATION;

D O I：

10.1039/c5cc01953b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Three new 10-membered macrolides, saccharothriolides A-C (1-3), were discovered from a rare actinomycete Saccharothrix sp. A1506. All of the sp(3) carbons in the 10-membered ring had chirality, which was determined by extensive spectroscopic analysis and TDDFT-calculation of ECD spectra. Saccharothriolide B (2) exhibited cytotoxicity against human tumor cell lines HeLa and HT1080.

引用

页码：8074 / 8077

页数：4

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