Electrochemical determination of epirubicin in the presence of topotecan as essential anti-cancer compounds using paste electrode amplified with Pt/SWCNT nanocomposite and a deep eutectic solvent

被引：13
作者：
Bavandpour, Razieh [1 ]
Rajabi, Maryam [1 ]
Asghari, Alireza [1 ]
机构：
[1] Semnan Univ, Dept Chem, Semnan 2333383193, Iran
来源：
CHEMOSPHERE | 2022年 / 289卷
关键词：
Anti -cancer drugs; Epirubicin; Pt-SWCNT nanocomposite; Deep eutectic solvent; Topotecan; VOLTAMMETRIC SENSOR; IONIC LIQUID; NANOPARTICLES; FABRICATION; WATER;
D O I：
10.1016/j.chemosphere.2021.133060
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Epirubicin (EP) and topotecan (TP) are two major anti-cancer compounds for the treatment of breast cancer with serious side effects. Hence herein, a carbon paste electrode (CPE) amplified with Pt/SWCNT nanocomposite and a deep eutectic solvent (CPE/DES/Pt-SWCNT) were proposed as an analytical tool for the monitoring of EP in the presence of TP in the real samples. Amplification of sensor was improve EP oxidation signal about 2.73 times. Under the optimized conditions, EP determined by using differential pulse voltammetry (DPV) technique with linear dynamic range of 0.001-500 mu M with limit of detection (LOD) of 0.8 nM. The CPE/DES/Pt-SWCNT offered influential ability for monitoring of EP in injection and dextrose saline samples with a recovery range of 97.4%- 104.9%.
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页数：7
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