Cortical spreading depression modifies components of the inflammatory cascade

被引：33

作者：

Thompson, CS ^{[1
]}

Hakim, AM ^{[1
]}

机构：

[1] Univ Ottawa, Ottawa Hlth Res Inst, Neurosci Res Program, Ottawa, ON, Canada

来源：

MOLECULAR NEUROBIOLOGY | 2005年 / 32卷 / 01期

关键词：

inflammation; stroke; cortical spreading depression; gene expression;

D O I：

10.1385/MN:32:1:051

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

As more information becomes available regarding the role of inflammation following stroke, it is apparent that some inflammatory mediators are detrimental and others are beneficial to the progression of ischemic injury. Cortical spreading depression (CSD) is known to impart some degree of ischemic tolerance to the brain and to influence the expression of many genes. Many of the genes whose expression is altered by CSD are associated with inflammation, and it appears likely that modulation of the inflammatory response to ischemia by CSD contributes to ischemic tolerance. Understanding which inflammatory processes are influenced by CSD may lead to the identification of novel targets in the effort to develop an acute treatment for stroke.

引用

页码：51 / 57

页数：7

共 33 条

[11] Multiplexed cytokine protein expression profiles from spreading depression in hippocampal organotypic cultures [J].

Kunkler, PE ;

Hulse, RE ;

Kraig, TP .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2004, 24 (08) :829-839

[12] Requirement for interleukin-12 in the pathogenesis of warm hepatic ischemia/reperfusion injury in mice [J].

Lentsch, AB ;

Yoshidome, H ;

Kato, A ;

Warner, RL ;

Cheadle, WG ;

Ward, PA ;

Edwards, MJ .

HEPATOLOGY, 1999, 30 (06) :1448-1453

[13] SENSORIMOTOR AND COGNITIVE CONSEQUENCES OF MIDDLE CEREBRAL-ARTERY OCCLUSION IN RATS [J].

MARKGRAF, CG ;

GREEN, EJ ;

HURWITZ, BE ;

MORIKAWA, E ;

DIETRICH, WD ;

MCCABE, PM ;

GINSBERG, MD ;

SCHNEIDERMAN, N .

BRAIN RESEARCH, 1992, 575 (02) :238-246

[14] Cortical spreading depression activates trophic factor expression, in neurons and astrocytes and protects against subsequent focal brain Ischemia [J].

Matsushima, K ;

Schmidt-Kastner, R ;

Hogan, MJ ;

Hakim, AM .

BRAIN RESEARCH, 1998, 807 (1-2) :47-60

[15]

Matsushima K, 1996, J CEREBR BLOOD F MET, V16, P221, DOI 10.1097/00004647-199603000-00006

[16] Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N-methyl-D-aspartic acid-receptors and phospholipase A(2) [J].

Miettinen, S ;

Fusco, FR ;

Yrjanheikki, J ;

Keinanen, R ;

Hirovonen, T ;

Roivainen, R ;

Narhi, M ;

Hokfelt, T ;

Koistinaho, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (12) :6500-6505

[17] Synergy of IL-12 and IL-18 for IFN-γ gene expression:: IL-12-induced STAT4 contributes to IFN-γ promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1 [J].

Nakahira, M ;

Ahn, HJ ;

Park, WR ;

Gao, P ;

Tomura, M ;

Park, CS ;

Hamaoka, T ;

Ohta, T ;

Kurimoto, M ;

Fujiwara, H .

JOURNAL OF IMMUNOLOGY, 2002, 168 (03) :1146-1153

[18] Nuclear factor-κB contributes to infarction after permanent focal ischemia [J].

Nurmi, A ;

Lindsberg, PJ ;

Koistinaho, M ;

Zhang, W ;

Juettler, E ;

Karjalainen-Lindsberg, ML ;

Weih, F ;

Frank, N ;

Schwaninger, M ;

Koistinaho, J .

STROKE, 2004, 35 (04) :987-991

[19] Cortical spreading depression causes a long-lasting decrease in cerebral blood flow and induces tolerance to permanent focal ischemia in rat brain [J].

Otori, T ;

Greenberg, TH ;

Welsh, FA .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2003, 23 (01) :43-50

[20] Prevention of neuron and oligodendrocyte degeneration by interleukin-6 (IL-6) and IL-6 receptor/IL-6 fusion protein in organotypic hippocampal slices [J].

Pizzi, M ;

Sarnico, I ;

Boroni, F ;

Benarese, M ;

Dreano, M ;

Garotta, G ;

Valerio, A ;

Spano, PF .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2004, 25 (02) :301-311

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