Antifungal Susceptibility Does Not Correlate With Fungal Clearance or Survival in AIDS-Associated Cryptococcal Meningitis

被引：14

作者：

O'Connor, Lucy ^{[1
]}

Duong Van Anh ^{[2
]}

Tran Thi Hong Chau ^{[2
]}

Nguyen Van Vinh Chau ^{[3
]}

Lan Nguyen Phu Huong ^{[3
]}

Wolbers, Marcel ^{[2
]}

Day, Jeremy N. ^{[2
,4
]}

机构：

[1] Guys & St Thomas NHS Trust, London, England

[2] Univ Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam

[3] Hosp Trop Dis, Ho Chi Minh City, Vietnam

[4] Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England

来源：

CLINICAL INFECTIOUS DISEASES | 2021年 / 73卷 / 07期

基金：

英国惠康基金;

关键词：

cryptococcal meningitis; susceptibility testing; HIV; outcome; mortality; FLUCONAZOLE; NEOFORMANS;

D O I：

10.1093/cid/ciaa1544

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated the value of susceptibility testing in predicting response in AIDS-associated cryptococcal meningitis using clinical isolates from a randomized controlled trial of antifungal treatment (amphotericin monotherapy, amphotericin with flucytosine, or amphotericin with fluconazole). We found no correlation between antifungal susceptibility and either early or late survival, or fungal clearance.

引用

页码：E2338 / E2341

页数：4

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