Carrier-free nanomedicine for enhanced photodynamic tumor therapy through glutathione S-transferase inhibition

被引：8
|
作者：
Li, Xinyu [1 ,2 ]
Kong, Renjiang [1 ,2 ]
Li, Yanmei [1 ,2 ]
Huang, Jiaqi [1 ,2 ]
Zhou, Xiang [1 ,2 ]
Li, Shiying [3 ]
Cheng, Hong [1 ,2 ]
机构：
[1] Southern Med Univ, Sch Biomed Engn, Guangzhou 510515, Peoples R China
[2] Southern Med Univ, Guangdong Prov Key Lab Construct & Detect Tissue, Guangzhou 510515, Peoples R China
[3] Guangzhou Med Univ, Sch Pharmaceut Sci, Guangzhou 511436, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 24期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
20;
D O I：
10.1039/d2cc00235c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Antioxidant-defense systems of tumor cells protect them from oxidative damage. Herein, a carrier-free nanomedicine is developed based on chlorine e6 (Ce6) and coniferyl ferulate (Con), which inhibits glutathione S-transferase (GST) activity to hamper antioxidant systems and amplify intracellular oxidative stress for enhanced photodynamic therapy.
引用
收藏
页码：3917 / 3920
页数：4
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