Heat shock proteins in mammalian development

被引：94
作者：
Christians, ES [1 ]
Zhou, Q
Renard, J
Benjamin, IJ
机构：
[1] Univ Utah, Sch Med, Dept Internal Med, Div Cardiol, Salt Lake City, UT 84132 USA
[2] INRA, UMR Biol Dev & Biotechnol, F-78352 Jouy En Josas, France
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2003年 / 14卷 / 05期
关键词：
heat shock factor; chaperone; embryo; heart; fertility;
D O I：
10.1016/j.semcdb.2003.09.021
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Mammalian development follows a defined but adjustable program, depending on the plasticity of embryonic cells 'response to environmental changes. Heat shock proteins (Hsp) are integral part of this developmental program and gene targeting experiments have started to unravel developmental processes, which exhibit specific requirements for Hsps (e.g. Hsp70.2 for spermatogenesis). In the present paper, we will review available data on Hsp function and discuss the roles of heat shock factors (HSF), their major regulators, in mammalian development. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：283 / 290
页数：8
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