BUBR1 EXPRESSION IN ORAL SQUAMOUS CELL CARCINOMA AND ITS RELATIONSHIP TO TUMOR STAGE AND SURVIVAL

被引：16
|
作者：
Rizzardi, Clara [1 ]
Torelli, Lucio [2 ]
Barresi, Elena [1 ]
Schneider, Manuela [3 ]
Canzonieri, Vincenzo [4 ]
Biasotto, Matteo [5 ]
Di Lenarda, Roberto [5 ]
Melato, Mauro [1 ]
机构：
[1] Univ Trieste, Dept Pathol & Forens Med, Trieste, Italy
[2] Univ Trieste, Dept Math & Comp Sci, Trieste, Italy
[3] Azienda Serv Sanit 2 Isontina, Unit Pathol, Gorizia, Italy
[4] IRCCS, Ist Nazl Tumori, Ctr Riferimento Oncol, Aviano, Italy
[5] Univ Trieste, Dept Biomed, Unit Dent & Stomatol, Trieste, Italy
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2011年 / 33卷 / 05期
关键词：
squamous cell carcinoma; oral; prognostic factor; spindle checkpoint; BUBR1; MITOTIC CHECKPOINT GENES; SPINDLE ASSEMBLY CHECKPOINT; CHROMOSOMAL INSTABILITY; CANCER-CELLS; HEPATOCELLULAR-CARCINOMA; BLADDER-CANCER; GASTRIC-CANCER; LUNG-CANCER; OVEREXPRESSION; ANEUPLOIDY;
D O I：
10.1002/hed.21532
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background. Defects in the mitotic spindle checkpoint have been proposed to contribute to the chromosomal instability observed in human cancers, including oral squamous cell carcinoma (OSCC). BUBR1 is a key component of the spindle checkpoint, whose role in oral carcinogenesis still needs to be clarified. Methods. We have analyzed the expression of BUBR1 in 49 cases of OSCC by immunohistochemistry and compared the findings with clinicopathologic parameters, proliferative activity, and DNA ploidy. Results. BUBR1 was overexpressed in 11 cases (22.4%). Tumors with overexpression of BUBR1 were associated with a less advanced pathologic stage (p = .05) and showed longer survival periods (p = .38) but shorter recurrence-free survival periods (p = .13) than those without it. Conclusions. Our data imply the possibility that BUBR1 may be involved in the progression of OSCC, and suggest that BUBR1 may be a promising prognostic marker in patients with OSCC. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 727-733, 2011
引用
收藏
页码：727 / 733
页数：7
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