Tomographic Ultrasound and LED-Based Photoacoustic System for Preclinical Imaging

被引:12
|
作者
Francis, Kalloor Joseph [1 ]
Booijink, Richell [2 ]
Bansal, Ruchi [2 ]
Steenbergen, Wiendelt [1 ]
机构
[1] Univ Twente, Tech Med Ctr, Biomed Photon Imaging BMPI, NL-7522 NH Enschede, Netherlands
[2] Univ Twente, Tech Med Ctr, Med Cell BioPhys MCBP, Translat Liver Res, NL-7522 NH Enschede, Netherlands
关键词
tomography; photoacoustic; ultrasound; small animal; liver; fibrosis; FIBROSIS;
D O I
10.3390/s20102793
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Small animals are widely used as disease models in medical research. Noninvasive imaging modalities with functional capability play an important role in studying the disease state and treatment progress. Photoacoustics, being a noninvasive and functional modality, has the potential for small-animal imaging. However, the conventional photoacoustic tomographic systems use pulsed lasers, making it expensive, bulky, and require long acquisition time. In this work, we propose the use of photoacoustic and ultrasound tomographic imaging with LEDs as the light source and acoustic detection using a linear transducer array. We have demonstrated full-view tomographic imaging of a euthanized mouse and a potential application in liver fibrosis research.
引用
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页数:8
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