Double-Headed Nucleotides: Building Blocks for New Nucleic Acid Architectures

被引：15
|
作者：
Sharma, Pawan K. [1 ]
Kumar, Pawan [2 ]
Nielsen, Poul [2 ]
机构：
[1] Kurukshetra Univ, Dept Chem, Kurukshetra 136119, Haryana, India
[2] Univ Southern Denmark, Dept Phys Chem & Pharm, Nucle Acid Ctr, DK-5230 Odense, Denmark
来源：
AUSTRALIAN JOURNAL OF CHEMISTRY | 2016年 / 69卷 / 10期
基金：
新加坡国家研究基金会;
关键词：
BASE-BASE INTERACTIONS; MINOR-GROOVE; SECONDARY STRUCTURES; DNA-NANOTECHNOLOGY; MAJOR GROOVE; DUPLEX; OLIGONUCLEOTIDES; NUCLEOBASE; STABILITY; 2ND-MESSENGER;
D O I：
10.1071/CH16021
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Double-headed nucleotides are nucleotides with two nucleobases. These have been investigated recently with the purpose of using the recognition potential of the additional nucleobases in various nucleic acid constructs. Presented here is a review of the double-headed nucleotide monomers investigated so far and their effects in nucleic acid duplexes and other secondary structures.
引用
收藏
页码：1094 / 1101
页数：8
相关论文
共 50 条
  • [1] Double-headed nucleotides introducing thymine nucleobases in the major groove of nucleic acid duplexes
    Dalager, Michael
    Andersen, Nicolai K.
    Kumar, Pawan
    Nielsen, Poul
    Sharma, Pawan K.
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 13 (25) : 7040 - 7049
  • [2] Double-headed nucleotides as xeno nucleic acids: information storage and polymerase recognition
    Beck, Kasper M.
    Krogh, Marie B.
    Hornum, Mick
    Ludford, Paul T.
    Tor, Yitzhak
    Nielsen, Poul
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2020, 18 (36) : 7213 - 7223
  • [3] Condensing the information in DNA with double-headed nucleotides
    Hornum, Mick
    Sharma, Pawan K.
    Reslow-Jacobsen, Charlotte
    Kumar, Pawan
    Petersen, Michael
    Nielsen, Poul
    CHEMICAL COMMUNICATIONS, 2017, 53 (70) : 9717 - 9720
  • [4] Double-headed nucleic acids condense the molecular information of DNA to half the number of nucleotides
    Beck, Kasper M.
    Sharma, Pawan K.
    Hornum, Mick
    Risgaard, Nikolaj A.
    Nielsen, Poul
    CHEMICAL COMMUNICATIONS, 2021, 57 (72) : 9128 - 9131
  • [5] Base-Pairing Properties of Double-Headed Nucleotides
    Hornum, Mick
    Stendevad, Julie
    Sharma, Pawan K.
    Kumar, Pawan
    Nielsen, Rasmus B.
    Petersen, Michael
    Nielsen, Poul
    CHEMISTRY-A EUROPEAN JOURNAL, 2019, 25 (30) : 7387 - 7395
  • [6] Double-Headed Nucleotides with Arabino Configuration: Synthesis and Hybridization Properties
    Kumar, Pawan
    Sharma, Pawan K.
    Nielsen, Poul
    JOURNAL OF ORGANIC CHEMISTRY, 2014, 79 (23): : 11534 - 11540
  • [7] The synthesis of double-headed nucleosides by the CuAAC reaction and their effect in secondary nucleic acid structures
    Jorgensen, Anna S.
    Shaikh, Khalil I.
    Enderlin, Gerald
    Ivarsen, Elise
    Kumar, Surender
    Nielsen, Poul
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2011, 9 (05) : 1381 - 1388
  • [8] Double-Coding Nucleic Acids: Introduction of a Nucleobase Sequence in the Major Groove of the DNA Duplex Using Double-Headed Nucleotides
    Kumar, Pawan
    Sorinas, Antoni Figueras
    Nielsen, Lise J.
    Slot, Maria
    Skytte, Kirstine
    Nielsen, Annie S.
    Jensen, Michael D.
    Sharma, Pawan K.
    Vester, Birte
    Petersen, Michael
    Nielsen, Poul
    JOURNAL OF ORGANIC CHEMISTRY, 2014, 79 (17): : 8020 - 8030
  • [9] Double-Headed Nucleotides with Increased Base-Pairing Affinity and Specificity
    Beck, Kasper M.
    Pham, Robert L.
    Nanim, Rita A.
    Laustsen, Anders
    Nielsen, Poul
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2021, 2021 (48) : 6717 - 6724
  • [10] Double-Headed Nucleotides with Non-Native Nucleobases: Synthesis and Duplex Studies
    Beck, Kasper M.
    Ruder, Linette
    Nicolai, Tine S.
    Pham, Robert L.
    Risgaard, Nikolaj A.
    Hornum, Mick
    Nielsen, Poul
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2021, 2021 (12) : 1949 - 1957
12345