Mechanisms of Staphylococcus aureus induced apoptosis of human endothelial cells

被引：118
作者：
Esen, M
Schreiner, B
Jendrossek, V
Lang, F
Fassbender, K
Grassmé, H
Gulbins, E
机构：
[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
[2] Univ Tubingen, Dept Physiol, D-72076 Tubingen, Germany
[3] Univ Heidelberg, Dept Neurol, D-68135 Mannheim, Germany
来源：
APOPTOSIS | 2001年 / 6卷 / 06期
关键词：
acid sphingomyelinase; apoptosis; caspases; endothelial cells; JNK; S; aureus;
D O I：
10.1023/A:1012445925628
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Staphylococcus aureus plays an important role in sepsis, pneumonia and wound infections. Here, we demonstrate that infection with several S. aureus strains results in apoptosis of human endothelial cells. S. aureus induced an activation of cellular caspases, the acid sphingomyelinase, a release of cytochrome c and a stimulation of Jun NH2-terminal kinase (JNK). The significance of these findings is indicated by a prevention of S. aureus triggered apoptosis of human cells deficient for ASM or upon genetic or pharmacological inhibition of JNK or caspases, respectively.
引用
收藏
页码：431 / 439
页数：9
相关论文
共 50 条
  • [21] Mechanisms of nordihydroguaiaretic acid-induced growth inhibition and apoptosis in human cancer cells
    Seufferlein T.
    Seckl M.J.
    Schwarz E.
    Beil M.
    Wichert G.V.
    Baust H.
    Lührs H.
    Schmid R.M.
    Adler G.
    British Journal of Cancer, 2002, 86 (7) : 1188 - 1196
  • [22] Pseudomonas aeruginosa induces apoptosis in human endothelial cells
    Valente, E
    Assis, MC
    Alvim, IMP
    Pereira, GMB
    Plotkowski, MC
    MICROBIAL PATHOGENESIS, 2000, 29 (06) : 345 - 356
  • [23] Effect of ghrelin on human endothelial cells apoptosis induced by high glucose
    Zhao, Hong
    Liu, GuoLiang
    Wang, QiuYue
    Ding, LiYing
    Cal, Hui
    Jiang, HaiHong
    Xin, Zhongqiu
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 362 (03) : 677 - 681
  • [24] Oxidative stress-induced apoptosis of endothelial cells
    Warren, MC
    Bump, EA
    Medeiros, D
    Braunhut, SJ
    FREE RADICAL BIOLOGY AND MEDICINE, 2000, 29 (06) : 537 - 547
  • [25] Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells
    Lin, Yani
    Yu, Miaomiao
    Fan, Tingjun
    TOXICOLOGY LETTERS, 2020, 320 : 9 - 18
  • [26] Mechanisms of nordihydroguaiaretic acid-induced growth inhibition and apoptosis in human cancer cells
    Seufferlein, T
    Seckl, MJ
    Schwarz, E
    Beil, M
    von Wichert, G
    Baust, H
    Lührs, H
    Schmid, RM
    Adler, G
    BRITISH JOURNAL OF CANCER, 2002, 86 (07) : 1188 - 1196
  • [27] Effect of dietary phenolic compounds on apoptosis of human cultured endothelial cells induced by oxidized LDL
    Vieira, O
    Escargueil-Blanc, I
    Meilhac, O
    Basile, JP
    Laranjinha, J
    Almeida, L
    Salvayre, R
    Nègre-Salvayre, A
    BRITISH JOURNAL OF PHARMACOLOGY, 1998, 123 (03) : 565 - 573
  • [28] Venlafaxine protects methylglyoxal-induced apoptosis in the cultured human brain microvascular endothelial cells
    Lv, Qinghua
    Gu, Chengyao
    Chen, Caijing
    NEUROSCIENCE LETTERS, 2014, 569 : 99 - 103
  • [29] FIBRINOGEN ACTS AS A BRIDGING MOLECULE IN THE ADHERENCE OF STAPHYLOCOCCUS-AUREUS TO CULTURED HUMAN ENDOTHELIAL-CELLS
    CHEUNG, AL
    KRISHNAN, M
    JAFFE, EA
    FISCHETTI, VA
    JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (06) : 2236 - 2245
  • [30] An in vitro investigation of the protective role of Staphylococcus Epidermidis extracts on Staphylococcus Aureus induced toxicity in human keratinocytes
    Mohammedsaeed, Walaa
    Manzoor, Nikhat
    INDIAN JOURNAL OF MEDICAL MICROBIOLOGY, 2022, 40 (02) : 239 - 244
12345