Mechanisms of Staphylococcus aureus induced apoptosis of human endothelial cells

被引：118
|
作者：
Esen, M
Schreiner, B
Jendrossek, V
Lang, F
Fassbender, K
Grassmé, H
Gulbins, E
机构：
[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
[2] Univ Tubingen, Dept Physiol, D-72076 Tubingen, Germany
[3] Univ Heidelberg, Dept Neurol, D-68135 Mannheim, Germany
来源：
APOPTOSIS | 2001年 / 6卷 / 06期
关键词：
acid sphingomyelinase; apoptosis; caspases; endothelial cells; JNK; S; aureus;
D O I：
10.1023/A:1012445925628
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Staphylococcus aureus plays an important role in sepsis, pneumonia and wound infections. Here, we demonstrate that infection with several S. aureus strains results in apoptosis of human endothelial cells. S. aureus induced an activation of cellular caspases, the acid sphingomyelinase, a release of cytochrome c and a stimulation of Jun NH2-terminal kinase (JNK). The significance of these findings is indicated by a prevention of S. aureus triggered apoptosis of human cells deficient for ASM or upon genetic or pharmacological inhibition of JNK or caspases, respectively.
引用
收藏
页码：431 / 439
页数：9
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