Proficiency testing programs for Alzheimer's disease cerebrospinal fluid biomarkers

被引：0

作者：

Mattsson, Niklas ^{[1
]}

Andreasson, Ulf ^{[1
]}

Carrillo, Maria C. ^{[2
]}

Persson, Staffan ^{[1
]}

Shaw, Leslie M. ^{[3
]}

Zegers, Ingrid ^{[4
]}

Zetterberg, Henrik ^{[1
,5
]}

Blennow, Kaj ^{[1
]}

机构：

[1] Univ Gothenburg, Sahlgrens Univ Hosp, Sahlgrenska Acad,Clin Neurochem Lab, Dept Psychiat & Neurochem,Inst Neurosci & Psychia, Molndal, Sweden

[2] Alzheimers Assoc, Dept Med & Sci Relat, Chicago, IL USA

[3] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[4] European Commiss, Joint Res Ctr, Inst Reference Mat & Measurements, Geel, Belgium

[5] UCL Inst Neurol, London, England

来源：

BIOMARKERS IN MEDICINE | 2012年 / 6卷 / 04期

关键词：

Alzheimer's disease; biomarkers; cerebrospinal fluid; proficiency testing; NEUROCHEMICAL DEMENTIA DIAGNOSTICS; MILD COGNITIVE IMPAIRMENT; ASSOCIATION WORKGROUPS; NATIONAL INSTITUTE; XMAP TECHNOLOGY; TAU-PROTEINS; RECOMMENDATIONS; PERFORMANCE; GUIDELINES;

D O I：

10.2217/BMM.12.41

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cerebrospinal fluid (CSF) biomarkers are increasingly used for diagnosis of Alzheimer's disease in research, clinical trials and clinical settings. As for other biochemical measurements, variability between laboratories for these biomarkers may be monitored by proficiency testing programs, where participating laboratories use their local routine methods to analyze test samples shipped from a central laboratory. In this review, we summarize the results from the last years' pilot proficiency programs and describe the ongoing standardization efforts in this area. Global proficiency testing for CSF biomarkers is now fully established. It will continue to play an important part in the standardization of measurements that is a prerequisite for the broad-scale future implementation of CSF biomarkers.

引用

页码：401 / 407

页数：7

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