The kynurenate analog SZR-72 prevents the nitroglycerol-induced increase of c-fos immunoreactivity in the rat caudal trigeminal nucleus:: Comparative studies of the effects of SZR-72 and kynurenic acid

被引：62
作者：
Knyihar-Csillik, E. [1 ]
Mihaly, A. [3 ]
Krisztin-Peva, B. [3 ]
Robotka, H. [2 ]
Szatmari, I. [2 ]
Fulop, F. [4 ]
Toldi, J. [2 ]
Csillik, B. [3 ]
Vecsei, L. [1 ]
机构：
[1] Univ Szeged, Albert Szent Gyorgyi Clin Ctr, Dept Neurol, H-6726 Szeged, Hungary
[2] Univ Szeged, Dept Comparat Physiol, H-6726 Szeged, Hungary
[3] Univ Szeged, Dept Anat, H-6726 Szeged, Hungary
[4] Univ Szeged, Dept Pharmaceut Chem, H-6726 Szeged, Hungary
来源：
NEUROSCIENCE RESEARCH | 2008年 / 61卷 / 04期
关键词：
caudal trigeminal nucleus; c-fos; kynurenic acid analog; nitroglycerol; migraine model;
D O I：
10.1016/j.neures.2008.04.009
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Administration of nitroglycerol in a migraine model results in an increased number of c-fos-expressing secondary sensory neurons in the caudal trigeminal nucleus. Since synapses between first- and second-order trigeminal neurons are mediated by excitatory amino acids, NMDA receptors are inhibited by kynurenic acid, though this crosses the blood-brain barrier only poorly. Systemic treatment of rats with SZR-72, a newly synthetized kynurenic acid analog, diminished the nitroglycerol-induced increase of c-fos immunoreactivity in the brain stem highly significantly, while treatment with kynurenic acid resulted in a significantly smaller decrease, proving that SZR-72 is much more effective than kynurenic acid. (C) 2008 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
引用
收藏
页码：429 / 432
页数：4
相关论文
共 20 条
[1]   EXPRESSION OF C-FOS-LIKE PROTEIN AS A MARKER FOR NEURONAL-ACTIVITY FOLLOWING NOXIOUS-STIMULATION IN THE RAT [J].
BULLITT, E .
JOURNAL OF COMPARATIVE NEUROLOGY, 1990, 296 (04) :517-530
[2]  
Centini C, 2007, ARCH ITAL BIOL, V145, P117
[3]   The NMDA receptor antagonist MK-801 reduces Fos-like immunoreactivity within the trigeminocervical complex following superior sagittal sinus stimulation in the cat [J].
Classey, JD ;
Knight, YE ;
Goadsby, PJ .
BRAIN RESEARCH, 2001, 907 (1-2) :117-124
[4]   Ethyl (3S,4aR,6S,8aR)-6-(4-ethoxycarbonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic ester:: A prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine [J].
Filla, SA ;
Winter, MA ;
Johnson, KW ;
Bleakman, D ;
Bell, MG ;
Bleisch, TJ ;
Castaño, AM ;
Clemens-Smith, A ;
del Prado, M ;
Dieckman, DK ;
Dominguez, E ;
Escribano, A ;
Ho, KH ;
Hudziak, KJ ;
Katofiasc, MA ;
Martinez-Perez, JA ;
Mateo, A ;
Mathes, BM ;
Mattiuz, EL ;
Ogden, AML ;
Phebus, LA ;
Stack, DR ;
Stratford, RE ;
Ornstein, PL .
JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (20) :4383-4386
[5]  
FORREST CM, 2005, KYNURENINES BRAIN EX, P51
[6]   BLOOD-BRAIN-BARRIER TRANSPORT OF KYNURENINES - IMPLICATIONS FOR BRAIN SYNTHESIS AND METABOLISM [J].
FUKUI, S ;
SCHWARCZ, R ;
RAPOPORT, SI ;
TAKADA, Y ;
SMITH, QR .
JOURNAL OF NEUROCHEMISTRY, 1991, 56 (06) :2007-2017
[7]   Glutamatergic transmission in the trigeminal nucleus assessed with local blood flow [J].
Goadsby, PJ ;
Classey, JD .
BRAIN RESEARCH, 2000, 875 (1-2) :119-124
[8]   Corticothalarnic synchronization beads to c-fos expression in the auditory tUarnus [J].
Guo, Yi Ping ;
Sun, Xia ;
Li, Chuan ;
Wang, Ning Qian ;
Chan, Ying-Shing ;
He, Jufang .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (28) :11802-11807
[9]   INDUCTION OF C-FOS-LIKE PROTEIN IN SPINAL-CORD NEURONS FOLLOWING SENSORY STIMULATION [J].
HUNT, SP ;
PINI, A ;
EVAN, G .
NATURE, 1987, 328 (6131) :632-634
[10]   Kynurenine in combination with probenecid mitigates the stimulation-induced increase of c-fos immunoreactivity of the rat caudal trigeminal nucleus in an experimental migraine model [J].
Knyihar-Csillik, E. ;
Toldi, J. ;
Mihaly, A. ;
Krisztin-Peva, B. ;
Chadaide, Z. ;
Nemeth, H. ;
Fenyo, R. ;
Vecsei, L. .
JOURNAL OF NEURAL TRANSMISSION, 2007, 114 (04) :417-421
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