The kynurenate analog SZR-72 prevents the nitroglycerol-induced increase of c-fos immunoreactivity in the rat caudal trigeminal nucleus:: Comparative studies of the effects of SZR-72 and kynurenic acid

被引:58
作者
Knyihar-Csillik, E. [1 ]
Mihaly, A. [3 ]
Krisztin-Peva, B. [3 ]
Robotka, H. [2 ]
Szatmari, I. [2 ]
Fulop, F. [4 ]
Toldi, J. [2 ]
Csillik, B. [3 ]
Vecsei, L. [1 ]
机构
[1] Univ Szeged, Albert Szent Gyorgyi Clin Ctr, Dept Neurol, H-6726 Szeged, Hungary
[2] Univ Szeged, Dept Comparat Physiol, H-6726 Szeged, Hungary
[3] Univ Szeged, Dept Anat, H-6726 Szeged, Hungary
[4] Univ Szeged, Dept Pharmaceut Chem, H-6726 Szeged, Hungary
关键词
caudal trigeminal nucleus; c-fos; kynurenic acid analog; nitroglycerol; migraine model;
D O I
10.1016/j.neures.2008.04.009
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Administration of nitroglycerol in a migraine model results in an increased number of c-fos-expressing secondary sensory neurons in the caudal trigeminal nucleus. Since synapses between first- and second-order trigeminal neurons are mediated by excitatory amino acids, NMDA receptors are inhibited by kynurenic acid, though this crosses the blood-brain barrier only poorly. Systemic treatment of rats with SZR-72, a newly synthetized kynurenic acid analog, diminished the nitroglycerol-induced increase of c-fos immunoreactivity in the brain stem highly significantly, while treatment with kynurenic acid resulted in a significantly smaller decrease, proving that SZR-72 is much more effective than kynurenic acid. (C) 2008 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
引用
收藏
页码:429 / 432
页数:4
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