An Efficient One-Pot Access to Quinazolinone Derivatives Using TiO2 Nanoparticles as Catalyst: Synthesis and Vasorelaxant Activity Evaluation

被引：22

作者：

Khalafi-Nezhad, Ali ^{[1
]}

Haghighi, Saghar Mowlazadeh ^{[1
]}

Purkhosrow, Azar ^{[2
]}

Panahi, Farhad ^{[1
]}

机构：

[1] Shiraz Univ, Shiraz 71454, Iran

[2] Shiraz Univ Med Sci, Sch Med, Dept Pharmacol, Cardiovasc Pharmacol Res Lab, Shiraz 71454, Iran

来源：

SYNLETT | 2012年 / 06期

关键词：

quinazolinone; multicomponent reaction; TiO2; nanoparticles; heterogeneous catalyst; vasorelaxant activity; SOLVENT-FREE CONDITIONS; 4(3H)-QUINAZOLINONE DERIVATIVES; HYDROGEN-PEROXIDE; HETEROCYCLIC SYNTHESIS; MICROWAVE IRRADIATION; DEPRESSANT ACTIVITY; CASCADE SYNTHESIS; RECEPTOR; DESIGN; NUCLEOSIDE;

D O I：

10.1055/s-0031-1290610

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of quinazolinone derivatives were successfully synthesized, via a three-component condensation reaction between anthranilic acid, acetic anhydride, and amines. This process was accomplished in the presence of catalytic amount of titanium dioxide nanoparticles (nano-TiO2), under solvent-free conditions. The synthesized compounds were evaluated for their vasorelaxant activity as they revealed a range of activities on the isolated thoracic rat aorta.

引用

收藏

页码：920 / 924

页数：5

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