RETRACTED: Long noncoding RNA PROX1-AS1 promoted ovarian cancer cell proliferation and metastasis by suppressing KLF6 (Retracted article. See vol. 24, pg. 7220, 2020)

被引：0
|
作者：
Zhao, L. [1 ]
Li, J-F [2 ]
Tong, X-J [3 ]
机构：
[1] XinJiang Med Univ, Affiliated Hosp 1, Dept Gynecol Ctr, Urumqi, Peoples R China
[2] WeiHai Municipal Hosp, Dept Ultrasound, Weihai, Peoples R China
[3] China Med Univ, Liaoning Canc Hosp & Inst, Canc Hosp, Dept Gynecol, Shenyang, Peoples R China
来源：
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2020年 / 24卷 / 12期
关键词：
Long noncoding RNAs; PROX1-AS1; Ovarian cancer; KLF6; COLORECTAL-CANCER; MIGRATION; P53;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
OBJECTIVE: Recently, the role of long noncoding RNAs (IncRNAs) in tumor progression has attracted much attention worldwide. Numerous studies have identified IncRNA PROX1-AS1 as an oncogene in cancers. Therefore, the aim of this research was to explore the function of PROX1-AS1 in the development of ovarian cancer. PATIENTS AND METHODS: PROX1-AS1 expression in both ovarian cancer patients and normal subjects was detected by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Subsequently, PROX1-AS1 shRNA was constructed and transfected in vitro. 3-(4,5-dimethylthiazol-2-y1)-2,5-diphenyl tetrazolium bromide (MTT) assay, colony formation assay, trans-well assay, and Matrigel assay were utilized to detect the function of PROX1-AS1 in ovarian cancer. In addition, the potential mechanism was explored using qRT-PCR and Western blot assay. RESULTS: PROX1-AS1 was highly expressed in ovarian carcinoma samples and cell lines (p<0.05). The proliferation, migration, and invasion of ovarian cells were significantly inhibited after PROX1-AS1 was downregulated in vitro (p<0.05). Besides, the mRNA and protein expressions of KLF6 were significantly promoted after PROX1-AS1 knockdown in ovarian cancer cells (p<0.05). Further functional assays showed that KLF6 expression was negatively correlated with PROX1-AS1 expression in ovarian cancer samples. CONCLUSIONS: PROX1-AS1 enhances the metastasis and proliferation of ovarian cancer cells via suppressing KLF6. Our findings suggest that PROX1-AS1 may be applied as a novel target for therapy of ovarian cancer.
引用
收藏
页码：6561 / 6568
页数：8
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