Novel targeted drugs for the treatment of multiple myeloma: from bench to bedside

被引：46
|
作者：
Bruno, B
Giaccone, L
Rotta, M
Anderson, K
Boccadoro, M
机构：
[1] Univ Turin, Div Ematol, Osped S Giovanni Battist, I-10126 Turin, Italy
[2] Dana Farber Canc Inst, Jerome Lipper Multiple Myeloma Ctr, Boston, MA 02115 USA
来源：
LEUKEMIA | 2005年 / 19卷 / 10期
关键词：
mutliple myeloma; new drugs; signaling pathways;
D O I：
10.1038/sj.leu.2403905
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Multiple myeloma remains an incurable plasma cell neoplasm. New insights into its pathogenesis have identified signaling pathways that have become potential therapeutic targets. It has clearly been established that intracellular regulatory proteins and interactions between malignant plasma cells and the bone marrow microenvironment play an important role in their survival and drug resistance. Several new agents associated with molecular targets are currently being investigated to design new treatment strategies aimed at prolonging survival and improving quality of life. This review illustrates their mechanisms of action and the possible future clinical applications.
引用
收藏
页码：1729 / 1738
页数：10
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