Targeting HDACs: A Promising Therapy for Alzheimer's Disease

被引：149
作者：
Xu, Ke [2 ]
Dai, Xue-Ling [1 ,3 ]
Huang, Han-Chang [1 ]
Jiang, Zhao-Feng [1 ,4 ]
机构：
[1] Beijing Union Univ, Coll Arts & Sci, Beijing 100191, Peoples R China
[2] Capital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R China
[3] Peking Univ, Dept Physiol & Pathophysiol, Sch Basic Med Sci, Beijing 100191, Peoples R China
[4] Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China
来源：
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2011年 / 2011卷
基金：
中国国家自然科学基金;
关键词：
HISTONE DEACETYLASE INHIBITORS; MOUSE MODEL; TAU PHOSPHORYLATION; MEMORY IMPAIRMENT; REGULATES MEMORY; ACETYLATION; REDUCTION; TOXICITY; DEFICITS; SIRT1;
D O I：
10.1155/2011/143269
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Epigenetic modifications like DNA methylation and histone acetylation play an important role in a wide range of brain disorders. Histone deacetylases (HDACs) regulate the homeostasis of histone acetylation. Histone deacetylase inhibitors, which initially were used as anticancer drugs, are recently suggested to act as neuroprotectors by enhancing synaptic plasticity and learning and memory in a wide range of neurodegenerative and psychiatric disorders, such as Alzheimer's disease (AD) and Parkinson's disease (PD). To reveal the physiological roles of HDACs may provide us with a new perspective to understand the mechanism of AD and to develop selective HDAC inhibitors. This paper focuses on the recent research progresses of HDAC proteins and their inhibitors on the roles of the treatment for AD.
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页数：5
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