Clinical Characteristics and Prognosis of Small Cell Carcinoma in the Nasopharynx: A Population-Based Study

被引:3
作者
Zhou, Yu-ling [1 ,2 ]
Peng, Ying-peng [1 ,2 ]
Liu, Qiao-dan [1 ,2 ]
Chen, Xian-zhen [3 ]
He, Jianzhong [4 ]
Wei, Wei [1 ,2 ]
Zhong, Gui-hua [1 ,2 ]
Zhang, Ya-qin [5 ]
Liu, Ye [4 ]
Pan, Jia-ying [3 ]
Feng, Shao-yan [3 ]
Liu, Zhi-gang [1 ,2 ]
机构
[1] Sun Yat Sen Univ, Affiliated Hosp 5, Canc Ctr, Zhuhai 519000, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Affiliated Hosp 5, Guangdong Prov Key Lab Biomed Imaging, Zhuhai, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Dept Otorhinolaryngol Head & Neck Surg, Affiliated Hosp 5, 52 Meihua East Rd, Zhuhai 519000, Guangdong, Peoples R China
[4] Sun Yat Sen Univ, Dept Pathol, Affiliated Hosp 5, Zhuhai, Guangdong, Peoples R China
[5] Sun Yat Sen Univ, Dept Radiol, Affiliated Hosp 5, Zhuhai, Guangdong, Peoples R China
关键词
nasopharyngeal small cell carcinoma; prognostic factors; SEER database; radiotherapy; clinical characteristics; TUMOR MUTATIONAL BURDEN; NEUROENDOCRINE CARCINOMA; OLDER; NECK; HEAD;
D O I
10.1177/10732748221087075
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background Nasopharyngeal small cell carcinoma (SmCC) is a rare histological type of nasopharyngeal cancer, and its prognosis remains poor. This study aimed to determine the clinical characteristics and survival prognostic factors of nasopharyngeal SmCC. Methods Detailed clinicopathologic and therapeutic characteristics of a patient diagnosed with nasopharyngeal SmCC were determined. Nasopharyngeal SmCC cases reported previously were reviewed and summarized. Furthermore, a retrospective analysis was performed on data from the Surveillance, Epidemiology, and End Results (SEER) Program database. Kaplan-Meier analysis was conducted to compare survival within groups. Univariate and multivariate analyses were performed to investigate prognostic factors. Results A nasopharyngeal SmCC patient treated with chemoradiotherapy who achieved 46 months long-term survival was reported. In reviewing 16 reported cases with epidemiologic and therapeutic details, we found most of nasopharyngeal SmCC patients were diagnosed with advanced grades and received chemoradiotherapy. In total, 13,993 cases of nasopharyngeal cancer were extracted from the SEER database, from which 57 nasopharyngeal SmCC cases were eventually screened out. The mean age of the patients was 55.70 years, and 64.9% of these cases were either grade III or IV; the median overall survival (OS) was 18 months. Statistically significant differences were observed in the OS values of groups categorized by age (P = .025) or radiotherapy (P = .037). Age (<70 years) and radiotherapy were identified as independent survival and prognostic factors. Conclusion Patients with nasopharyngeal SmCC are usually diagnosed with advanced grades and have poor prognoses; nevertheless, they can benefit from radiotherapy with prolonged overall survival.
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页数:12
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