Stem cell-mediated muscle regeneration is enhanced by local isoform of insulin-like growth factor 1

被引：190

作者：

Musarò, A

Giacinti, C

Borsellino, G

Dobrowolny, G

Pelosi, L

Cairns, L

Ottolenghi, S

Cossu, G

Bernardi, G

Battistini, L

Molinaro, M

Rosenthal, N ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Hist & Med Embryol, I-00161 Rome, Italy

[2] Univ Roma La Sapienza, Ctr Eccellenza Biol & Med Mol, I-00161 Rome, Italy

[3] Edith Cowan Univ, Perth, WA 6027, Australia

[4] St Lucia Fdn Sci Inst, Neuroimmunol Unit, I-00100 Rome, Italy

[5] Dipartimento Biotecnol & Biosci, I-20126 Milan, Italy

[6] Univ Rome, Dept Neurosci, I-00100 Rome, Italy

[7] Mouse Biol Programme, European Mol Biol Lab, I-00016 Scalo, Italy

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2004年 / 101卷 / 05期

关键词：

D O I：

10.1073/pnas.0303792101

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We investigated the mechanism whereby expression of a transgene encoding a locally acting isoform of insulin-like growth factor 1 (mIGF-1) enhances repair of skeletal muscle damage. increased recruitment of proliferating bone marrow cells to injured MLC/ mIgf-1 transgenic muscles was accompanied by elevated bone marrow stem cell production in response to distal trauma. Regenerating MLC/mIgf-1 transgenic muscles contained increased cell populations expressing stem cell markers, exhibited accelerated myogenic differentiation, expressed markers of regeneration and readily converted cocultured bone marrow to muscle. These data implicate mIGF-1 as a powerful enhancer of the regeneration response, mediating the recruitment of bone marrow cells to sites of tissue damage and augmenting local repair mechanisms.

引用

页码：1206 / 1210

页数：5

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[1] Myogenic specification of side population cells in skeletal muscle [J].