BACKGROUND/OBJECTIVES: Aster yomena (Kitam.) Honda (AY) has remarkable bioactivities, such as antioxidant, anti-inflammation, and anti-cancer activities. On the other hand, the effects of AY against obesity-induced insulin resistance have not been reported. Therefore, this study examined the potential of AY against obesity-associated insulin resistance in high fat diet (HFD)-fed mice. MATERIALS/METHODS: An obesity model was established by feeding C57BL/6J mice a 60% HFD for 16 weeks. The C57BL6/When ethyl acetate fraction from AY (EFAY) at doses of 100 and 200 mg/kg/day was administered orally to mice fed a HFD for the last 4 weeks. Normal and control groups were administered water orally. The body weight and fasting blood glucose were measured every week. Dietary intake was measured every other day. After dissection, blood and tissues were collected from the mice. RESULTS: The administration of EFAY reduced body and organ weights significantly compared to HFD-fed control mice. The EFAY-administered groups also improved the serum lipid profile by decreasing the triglyceride, total cholesterol, and low-density lipoprotein compared to the control group. In addition, EFAY ameliorated the insulin resistance-related metabolic dysfunctions, including the fasting blood glucose and serum insulin level, compared to the HFD-fed control mice. The EFAY inhibited lipid synthesis and insulin resistance by down-regulation of hepatic fatty acid synthase and up-regulation of the AMP activated protein kinase pathway. EFAY also reduced lipid peroxidation in the liver, indicating that EFAY protected hepatic injury induced by obesity. CONCLUSIONS: These results suggest that EFAY improved obesity-associated insulin resistance by regulating the lipid and glucose metabolism, suggesting that AY could be used as a functional food to prevent obesity and insulin resistance.
机构:
Wonkwang Univ, Dept Oriental Pharm, Iksan 570749, South Korea
Wonkwang Univ, Wonkwang Oriental Med Res Inst, Iksan 570749, South KoreaWonkwang Univ, Dept Oriental Pharm, Iksan 570749, South Korea
Pandeya, Prakash Raj
Lamichhane, Gopal
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Wonkwang Univ, Dept Oriental Pharm, Iksan 570749, South Korea
Wonkwang Univ, Wonkwang Oriental Med Res Inst, Iksan 570749, South KoreaWonkwang Univ, Dept Oriental Pharm, Iksan 570749, South Korea
Lamichhane, Gopal
Lamichhane, Ramakanta
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Wonkwang Univ, Dept Oriental Pharm, Iksan 570749, South Korea
Wonkwang Univ, Wonkwang Oriental Med Res Inst, Iksan 570749, South KoreaWonkwang Univ, Dept Oriental Pharm, Iksan 570749, South Korea
Lamichhane, Ramakanta
Luo, Jiao
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Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Peoples R ChinaWonkwang Univ, Dept Oriental Pharm, Iksan 570749, South Korea
Luo, Jiao
Li, Xiao-Jun
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Gannan Med Univ, Natl Engn Res Ctr Modernizat Tradit Chinese Med, Sch Pharm, Hakka Med Resources Branch, Ganzhou 341000, Jiangxi, Peoples R ChinaWonkwang Univ, Dept Oriental Pharm, Iksan 570749, South Korea
Li, Xiao-Jun
Rhee, Su-jin
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Wonkwang Univ, Dept Pharm, Iksan 570749, South KoreaWonkwang Univ, Dept Oriental Pharm, Iksan 570749, South Korea
Rhee, Su-jin
Xiangqian, Liu
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Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Peoples R ChinaWonkwang Univ, Dept Oriental Pharm, Iksan 570749, South Korea
Xiangqian, Liu
Jung, Hyun-Ju
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Wonkwang Univ, Dept Oriental Pharm, Iksan 570749, South Korea
Wonkwang Univ, Wonkwang Oriental Med Res Inst, Iksan 570749, South KoreaWonkwang Univ, Dept Oriental Pharm, Iksan 570749, South Korea
机构:Wonkwang Univ, Coll Pharm, VestibuloCochlear Res Ctr, Iksan 570749, Jeonbuk, South Korea
An, HJ
Chung, HS
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机构:Wonkwang Univ, Coll Pharm, VestibuloCochlear Res Ctr, Iksan 570749, Jeonbuk, South Korea
Chung, HS
An, NH
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机构:Wonkwang Univ, Coll Pharm, VestibuloCochlear Res Ctr, Iksan 570749, Jeonbuk, South Korea
An, NH
Park, RK
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机构:Wonkwang Univ, Coll Pharm, VestibuloCochlear Res Ctr, Iksan 570749, Jeonbuk, South Korea
Park, RK
Kim, SH
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机构:Wonkwang Univ, Coll Pharm, VestibuloCochlear Res Ctr, Iksan 570749, Jeonbuk, South Korea
Kim, SH
Kim, CH
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机构:Wonkwang Univ, Coll Pharm, VestibuloCochlear Res Ctr, Iksan 570749, Jeonbuk, South Korea
Kim, CH
Kim, YK
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机构:Wonkwang Univ, Coll Pharm, VestibuloCochlear Res Ctr, Iksan 570749, Jeonbuk, South Korea
Kim, YK
Kim, HM
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机构:Wonkwang Univ, Coll Pharm, VestibuloCochlear Res Ctr, Iksan 570749, Jeonbuk, South Korea
Kim, HM
Hong, SH
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Wonkwang Univ, Coll Pharm, VestibuloCochlear Res Ctr, Iksan 570749, Jeonbuk, South KoreaWonkwang Univ, Coll Pharm, VestibuloCochlear Res Ctr, Iksan 570749, Jeonbuk, South Korea
机构:
Chonbuk Natl Univ, Dept Food Sci & Human Nutr, Jeonju Si 561756, Jeollabuk Do, South Korea
Chonbuk Natl Univ, Res Inst Humans Ecol, Jeonju Si 561756, Jeollabuk Do, South KoreaChonbuk Natl Univ, Dept Food Sci & Human Nutr, Jeonju Si 561756, Jeollabuk Do, South Korea
Bae, Cho-Rong
Kwon, Dae-Young
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Korea Food Res Inst, Korea Food Res Div, Songnam, South KoreaChonbuk Natl Univ, Dept Food Sci & Human Nutr, Jeonju Si 561756, Jeollabuk Do, South Korea
Kwon, Dae-Young
Cha, Youn-Soo
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Chonbuk Natl Univ, Dept Food Sci & Human Nutr, Jeonju Si 561756, Jeollabuk Do, South Korea
Chonbuk Natl Univ, Res Inst Humans Ecol, Jeonju Si 561756, Jeollabuk Do, South KoreaChonbuk Natl Univ, Dept Food Sci & Human Nutr, Jeonju Si 561756, Jeollabuk Do, South Korea