Concentrations of IGF-I and IGFBP-3 and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition

被引：38

作者：

Rohrmann, S. ^{[1
,2
]}

Grote, V. A. ^{[2
]}

Becker, S. ^{[2
,3
]}

Rinaldi, S. ^{[4
]}

Tjonneland, A. ^{[5
]}

Roswall, N. ^{[5
]}

Gronbaek, H. ^{[6
]}

Overvad, K. ^{[7
]}

Boutron-Ruault, M. C. ^{[8
,9
]}

Clavel-Chapelon, F. ^{[8
,9
]}

Racine, A. ^{[8
,9
]}

Teucher, B. ^{[3
]}

Boeing, H. ^{[10
]}

Drogan, D. ^{[10
]}

Dilis, V. ^{[11
]}

Lagiou, P. ^{[12
,13
,14
]}

Trichopoulou, A. ^{[11
,12
]}

Palli, D. ^{[15
]}

Tagliabue, G. ^{[16
]}

Tumino, R. ^{[17
]}

Vineis, P. ^{[18
,19
]}

Mattiello, A. ^{[20
]}

Rodriguez, L. ^{[21
]}

Duell, E. J. ^{[22
]}

Molina-Montes, E. ^{[23
]}

Dorronsoro, M. ^{[24
]}

Huerta, J-M ^{[25
]}

Ardanaz, E. ^{[26
]}

Jeurnink, S. ^{[27
,28
]}

Peeters, P. H. M. ^{[29
]}

Lindkvist, B. ^{[30
]}

Johansen, D. ^{[31
]}

Sund, M. ^{[32
,33
,34
]}

Ye, W. ^{[35
,36
]}

Khaw, K-T ^{[37
]}

Wareham, N. J. ^{[38
]}

Allen, N. E. ^{[39
]}

Crowe, F. L. ^{[39
]}

Fedirko, V. ^{[4
]}

Jenab, M. ^{[4
]}

Michaud, D. S. ^{[18
,40
]}

Norat, T. ^{[18
]}

Riboli, E.

Bueno-de-Mesquita, H. B. ^{[27
,28
]}

Kaaks, R. ^{[2
]}

机构：

[1] Univ Zurich, Inst Social & Prevent Med, Div Canc Epidemiol & Prevent, CH-8001 Zurich, Switzerland

[2] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[3] Univ Hosp Leipzig, Inst Lab Med Clin Chem & Mol Diagnost, Leipzig, Germany

[4] Int Agcy Res Canc IARC WHO, Lyon, France

[5] Danish Canc Soc, Copenhagen, Denmark

[6] Aarhus Univ Hosp, Dept Med 5, DK-8000 Aarhus, Denmark

[7] Aarhus Univ, Sch Publ Hlth, Dept Epidemiol, Aarhus, Denmark

[8] Inst Gustave Roussy, Ctr Res Epidemiol & Populat Hlth, INSERM, Villejuif, France

[9] Paris S Univ, Villejuif, France

[10] German Inst Human Nutr, Dept Epidemiol, Nuthetal, Germany

[11] Hellen Hlth Fdn, Athens, Greece

[12] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Food & Nutr Policies, GR-11527 Athens, Greece

[13] Acad Athens, Bur Epidemiol Res, Athens, Greece

[14] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[15] Canc Res & Prevent Inst ISPO, Mol & Nutrit Epidemiol Unit, Florence, Italy

[16] Fdn IRCCS Ist Nazl Tumori, Lombardy Canc Registry & Environm Epidemiol Unit, Milan, Italy

[17] Civile MP Arezzo Hosp, Canc Registry & Histopathol Unit, Ragusa, Italy

[18] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England

[19] HuGeF Fdn, Turin, Italy

[20] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[21] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain

[22] Catalan Inst Oncol ICO IDIBELL, Unit Nutr Environm & Canc, Barcelona, Spain

[23] Andalusian Sch Publ Hlth, Granada, Spain

[24] Publ Hlth Div Gipuzkoa, Basque Reg Hlth Dept, San Sebastian, Spain

[25] Murcia Reg Hlth Author, Dept Epidemiol, Murcia, Spain

[26] Navarre Publ Hlth Inst, Pamplona, Spain

[27] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[28] Univ Med Ctr Utrecht UMCU, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[29] Univ Med Ctr Utrecht, Julius Ctr, Utrecht, Netherlands

[30] Univ Gothenburg, Sahlgrenska Acad, Inst Med, Gothenburg, Sweden

[31] Skane Univ Hosp, SUS, Dept Surg, Malmo, Sweden

[32] Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden

[33] Umea Univ, Dept Surg & Publ Hlth & Clin Med, Umea, Sweden

[34] Umea Univ, Dept Nutr Res, Umea, Sweden

[35] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[36] Umea Univ, Med Biobank, Umea, Sweden

[37] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England

[38] Med Res Council MRC Epidemiol Unit, Cambridge, England

[39] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England

[40] Brown Univ, Div Biol & Med, Dept Epidemiol, Providence, RI 02912 USA

来源：

BRITISH JOURNAL OF CANCER | 2012年 / 106卷 / 05期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

IGF-I; IGFBP-3; pancreatic cancer; cohort study; GROWTH-FACTOR-I; FACTOR BINDING PROTEIN-3; EPIC PROJECT; SERUM-LEVELS; FACTOR-ALPHA; C-PEPTIDE; INSULIN; PROSTATE; GLUCOSE; WOMEN;

D O I：

10.1038/bjc.2012.19

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BACKGROUND: Insulin-like growth factors (IGFs) and their binding proteins (BPs) regulate cell differentiation, proliferation and apoptosis, and may have a role in the aetiology of various cancers. Information on their role in pancreatic cancer is limited and was examined here in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. METHODS: Serum concentrations of IGF-I and IGFBP-3 were measured using enzyme-linked immunosorbent assays in 422 cases and 422 controls matched on age, sex, study centre, recruitment date, and time since last meal. Conditional logistic regression was used to compute odds ratios (OR) and 95% confidence intervals (CI) adjusted for confounding variables. RESULTS: Neither circulating levels of IGF-I (OR = 1.21, 95% CI 0.75-1.93 for top vs bottom quartile, P-trend 0.301), IGFBP-3 (OR = 1.00, 95% CI 0.66-1.51, P-trend 0.79), nor the molar IGF-I/IGFBP-3 ratio, an indicator of free IGF-I level (OR = 1.22, 95% CI 0.75-1.97, P-trend 0.27), were statistically significantly associated with the risk of pancreatic cancer. In a cross-classification, however, a high concentration of IGF-I with concurrently low levels of IGFBP-3 was related to an increased risk of pancreatic cancer (OR = 1.72, 95% CI 1.05-2.83; P-interaction = 0.154). CONCLUSION: On the basis of these results, circulating levels of components of the IGF axis do not appear to be the risk factors for pancreatic cancer. However, on the basis of the results of a subanalysis, it cannot be excluded that a relatively large amount of IGF-1 together with very low levels of IGFBP-3 might still be associated with an increase in pancreatic cancer risk. British Journal of Cancer (2012) 106, 1004-1010. doi:10.1038/bjc.2012.19 www.bjcancer.com Published online 7 February 2012 (C) 2012 Cancer Research UK

引用

页码：1004 / 1010

页数：7

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