Cytotoxic constituents from Podocarpus fasciculus

被引：38

作者：

Kuo, Yu-Jen ^{[1
,2
]}

Hwang, Shy-Yuan ^{[3
]}

Wu, Ming-Der ^{[4
]}

Liao, Chia-Ching ^{[1
]}

Liang, Yu-Han ^{[1
]}

Kuo, Yao-Haur ^{[1
,5
]}

Ho, Hsiu-O ^{[2
]}

机构：

[1] Natl Res Inst Chinese Med, Taipei 112, Taiwan

[2] Taipei Med Univ, Sch Pharm, Taipei 110, Taiwan

[3] Endem Species Res Inst, Div Botany, Nantou 552, Taiwan

[4] Food Ind Res & Dev Inst, Hsinchu 300, Taiwan

[5] Chinese Med Univ, Grad Inst Integrated MEd, Taichung 404, Taiwan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2008年 / 56卷 / 04期

关键词：

podocarpus fasciculus; Podocarpaceae; 16-hydroxy communic acid; cytotoxic activity;

D O I：

10.1248/cpb.56.585

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new diterpene, 16-hydroxy communic acid (1), along with thirty one known compounds including live norditerpenes (2-6), twenty two flavonoids containing four billavonoids (7-10), nine monoflavonoids (11-19) and nine flavanoid glycosides (20-28), as well as four phenolic constituents (29-32) were isolated from the 95% ethanolic extract of Podocarpus fascieulus. The structure of 1 was elucidated using spectral methods. Of these isolates, nagilactone C (2) showed the most significant inhibitory effects against DLD cells (human colon carcinoma) (ED50= 2.57 mu g/ml) and compounds 7, 8, 10, 11, and 12 had moderate cytotoxic activity against human KB (human oral epithelium carcinoma), Hela (human cervical carcinoma), Hepa (human hepatoma), DLD (colon carcinoma), and A-549 (human lung carcinoma) tumor cell lines. Preliminary structure-activity relationship studies of the isolated diterpenoids and biflavonoids are discussed.

引用

页码：585 / 588

页数：4

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