Antcin C Enhances Cellular Apoptosis of Hepatic Carcinoma Cells by Modulating Phosphoinositide 3-Kinases/Protein Kinase B/The Mammalian Target of Rapamycin Pathway

被引：0
|
作者：
Ti, Zhenyu [1 ]
Wang, Xiaofeng [1 ]
Xu, Quanlin [1 ]
Wu, Xiaojun [1 ]
Chen, Wenhao [1 ]
Yan, Man [1 ]
机构：
[1] Northwest Univ, Dept Gen Surg, Xian Hosp 3, Affiliated Hosp, 10 Feng Cheng 3rd Rd, Xian 710021, Shaanxi, Peoples R China
来源：
CURRENT TOPICS IN NUTRACEUTICAL RESEARCH | 2022年 / 20卷 / 03期
关键词：
Antcin C; Apoptosis; Cell viability; Hepatic carcinoma; MATRIX METALLOPROTEINASES; CYCLE ARREST; IN-VIVO; INVASION; METASTASIS; ACTIVATION; MMP-9;
D O I：
10.37290/ctnr2641-452X.20:454-460
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
The present study has evaluated the role of Antcin C in hepatic carcinoma and its possible mechanism of action. The results show that Antcin C causes a significant dose-dependent reduction in cell viability, cell migration and invasion, and enhancement of apoptosis. Moreover, treatment with Antcin C significantly reduces the expression of phosphoinositide 3-kinases/protein kinase B protein in Hep-G2 cells in a concentration-dependent manner. In conclusion, data of the present investigation supports that Antcin C enhances apoptosis in hepatic carcinoma by inhibiting the phosphoinositide 3-kinases/ protein kinase B pathway.
引用
收藏
页码：454 / 460
页数：7
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