Antcin C Enhances Cellular Apoptosis of Hepatic Carcinoma Cells by Modulating Phosphoinositide 3-Kinases/Protein Kinase B/The Mammalian Target of Rapamycin Pathway

被引：0
|
作者：
Ti, Zhenyu [1 ]
Wang, Xiaofeng [1 ]
Xu, Quanlin [1 ]
Wu, Xiaojun [1 ]
Chen, Wenhao [1 ]
Yan, Man [1 ]
机构：
[1] Northwest Univ, Dept Gen Surg, Xian Hosp 3, Affiliated Hosp, 10 Feng Cheng 3rd Rd, Xian 710021, Shaanxi, Peoples R China
来源：
CURRENT TOPICS IN NUTRACEUTICAL RESEARCH | 2022年 / 20卷 / 03期
关键词：
Antcin C; Apoptosis; Cell viability; Hepatic carcinoma; MATRIX METALLOPROTEINASES; CYCLE ARREST; IN-VIVO; INVASION; METASTASIS; ACTIVATION; MMP-9;
D O I：
10.37290/ctnr2641-452X.20:454-460
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
The present study has evaluated the role of Antcin C in hepatic carcinoma and its possible mechanism of action. The results show that Antcin C causes a significant dose-dependent reduction in cell viability, cell migration and invasion, and enhancement of apoptosis. Moreover, treatment with Antcin C significantly reduces the expression of phosphoinositide 3-kinases/protein kinase B protein in Hep-G2 cells in a concentration-dependent manner. In conclusion, data of the present investigation supports that Antcin C enhances apoptosis in hepatic carcinoma by inhibiting the phosphoinositide 3-kinases/ protein kinase B pathway.
引用
收藏
页码：454 / 460
页数：7
相关论文
共 50 条
  • [1] The Local Anaesthetic Lignocaine Exhibits Potent Antilung Cancer Cell Activity by Inhibiting the Phosphoinositide 3-Kinases/Mammalian Target of Rapamycin/Mammalian Target of Rapamycin Pathway
    Dong, Quanling
    Mao, Zhifu
    PHARMACOLOGY, 2019, 104 (3-4) : 139 - 146
  • [2] Lupeol Inhibits Proliferation and Promotes Apoptosis of Ovarian Cancer Cells by Inactivating Phosphoinositide-3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin Pathway
    Chen, Feng
    Zhang, Bei
    CURRENT TOPICS IN NUTRACEUTICAL RESEARCH, 2021, 19 (02) : 206 - 210
  • [3] Trastuzumab regulates phosphoinositide 3 kinase/protein kinase B/mammalian target of rapamycin pathway to improve chemotherapy resistance in lymphoma cells
    Tan, Mingfang
    Wang, Xiaobo
    Chen, Diandian
    Dong, Lihua
    Hu, Yili
    MATERIALS EXPRESS, 2023, 13 (06) : 993 - 1001
  • [4] Efficacy of self-made Gengnian decoction on phosphatidylinositol 3-kinases/protein kinase B/mammalian target of rapamycin signaling pathway in perimenopausal rats
    Zhang Fan
    Cao Junyan
    Zhang Xin
    Wang Jing
    Yi Xu
    JOURNAL OF TRADITIONAL CHINESE MEDICINE, 2019, 39 (06) : 861 - 866
  • [5] Efficacy of self-made Gengnian decoction on phosphatidylinositol 3-kinases/protein kinase B/mammalian target of rapamycin signaling pathway in perimenopausal rats
    Zhang Fan
    Cao Junyan
    Zhang Xin
    Wang Jing
    Yi Xu
    JournalofTraditionalChineseMedicine, 2019, 39 (06) : 861 - 866
  • [6] Phosphoinositide-3 Kinase/Protein Kinase-B/Mammalian Target of Rapamycin Pathway in Psoriasis Pathogenesis. A Potential Therapeutic Target?
    Huang, Tian
    Un, Xiran
    Meng, Xianmin
    Lin, Mao
    ACTA DERMATO-VENEREOLOGICA, 2014, 94 (04) : 371 - 379
  • [7] Xihuang pills induce apoptosis in hepatocellular carcinoma by suppressing phosphoinositide 3-kinase/protein kinase-B/mechanistic target of rapamycin pathway
    Yong-Jie Teng
    Zhe Deng
    Zhao-Guang Ouyang
    Qing Zhou
    Si Mei
    Xing-Xing Fan
    Yong-Rong Wu
    Hong-Ping Long
    Le-Yao Fang
    Dong-Liang Yin
    Bo-Yu Zhang
    Yin-Mei Guo
    Wen-Hao Zhu
    Zhen Huang
    Piao Zheng
    Di-Min Ning
    Xue-Fei Tian
    World Journal of Gastrointestinal Oncology, 2022, (04) : 872 - 886
  • [8] Xihuang pills induce apoptosis in hepatocellular carcinoma by suppressing phosphoinositide 3-kinase/protein kinase-B/mechanistic target of rapamycin pathway
    Teng, Yong-Jie
    Deng, Zhe
    Ouyang, Zhao-Guang
    Zhou, Qing
    Mei, Si
    Fan, Xing-Xing
    Wu, Yong-Rong
    Long, Hong-Ping
    Fang, Le-Yao
    Yin, Dong-Liang
    Zhang, Bo-Yu
    Guo, Yin-Mei
    Zhu, Wen-Hao
    Huang, Zhen
    Zheng, Piao
    Ning, Di-Min
    Tian, Xue-Fei
    WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2022, 14 (04) : 872 - 886
  • [9] Interferon α-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway
    Thyrell, L
    Hjortsberg, L
    Arulampalam, V
    Panaretakis, T
    Uhles, S
    Dagnell, M
    Zhivotovsky, B
    Leibiger, I
    Grandér, D
    Pokrovskaja, K
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (23) : 24152 - 24162
  • [10] Leptin protects chondrocytes by inhibiting autophagy via phosphoinositide 3 kinase/protein kinase B/mammalian target of rapamycin signaling pathway
    Li, Ping
    Jiang, Weiqian
    Yang, Qiming
    Lu, Yang
    Zhang, Jian
    HELIYON, 2024, 10 (15)
12345