Tubulopapillary carcinoma of the mammary gland in a maned wolf (Chrysocyon brachyurus): histopathological and immunophenotypical analysis

被引:4
作者
Gamba, C. O. [1 ]
Damasceno, K. A. [1 ]
Ferreira, E. [1 ]
Malta, M. C. C. [2 ]
Cassali, G. D. [1 ]
机构
[1] Univ Fed Minas Gerais, Inst Ciencias Biol, BR-31270901 Belo Horizonte, MG, Brazil
[2] Fundacao Zoobot, Belo Horizonte, MG, Brazil
关键词
Chrysocyon brachyurus; female maned wolf; immunohistochemistry; mammary gland; tubulopapillary carcinoma; CANINE; EXPRESSION; TUMORS;
D O I
10.1590/S0102-09352011000600014
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
A maned female wolf (Chrysocyon brachyurus) showed nodules in the inguinal and left abdominal cranial mammary glands. The mammary gland was surgically excised, and microscopic analysis revealed epithelial cell proliferation in a tubular and papillary pattern; delicate fibrovascular stalks presenting numerous layers of moderately pleomorfic epithelial cells were observed. This histologic appearance was compatible with a diagnosis of mammary tubulopapillary carcinoma. The immunohistochemical profile revealed nuclear positivity for estrogen (70%) and progesterone (at least 90% of the neoplastic cells). The myoepithelium-associated with neoplastic cells lacked integrity, as evidenced by failed smooth muscle alpha actin reactivity in microinvasive areas. A low proliferation index was observed (3.4%). To the authors' knowledge, the present case represents the first finding of female tubulopapillary carcinoma in a mammary gland in this species.
引用
收藏
页码:1377 / 1381
页数:5
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