One-Pot Four-Component Synthesis of N2-Alkyl-N3-[2-(1,3,4-oxadiazol-2-yl)aryl]benzofuran-2,3-diamines

被引：11

作者：

Adib, Mehdi ^{[1
]}

Sheikhi, Ehsan ^{[1
]}

Karimzadeh, Morteza ^{[1
]}

Bijanzadeh, Hamid Reza ^{[2
]}

Amanlou, Massoud ^{[3
,4
]}

机构：

[1] Univ Tehran, Sch Chem, Univ Coll Sci, Tehran, Iran

[2] Tarbiat Modares Univ, Dept Chem, Tehran, Iran

[3] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, Tehran, Iran

[4] Univ Tehran Med Sci, Dept Med Chem, Tehran, Iran

来源：

HELVETICA CHIMICA ACTA | 2012年 / 95卷 / 05期

关键词：

Benzofuran-2; 3-diamines; Multicomponent reactions; PALLADIUM-CATALYZED HETEROANNULATION; SOLID-PHASE SYNTHESIS; SUR LE BENZOFURANNE; MULTICOMPONENT REACTIONS; 3-COMPONENT REACTION; EFFICIENT SYNTHESIS; COUPLING REACTIONS; FURAN-DERIVATIVES; CASCADE REACTIONS; ACID-DERIVATIVES;

D O I：

10.1002/hlca.201100403

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple synthesis of N2-alkyl-N3-[2-(1,3,4-oxadiazol-2-yl)aryl]benzofuran-2,3-diamines 5 via a one-pot four-component reaction is described (Scheme 1). A mixture of N-(isocyanoimino)triphenylphosphorane (1), a 2-aminobenzoic acid 2, a 2-hydroxybenzaldehyde 3, and an isocyanide 4 in absolute EtOH at room temperature undergoes a smooth reaction to afford 5 in excellent yields (Table).

引用

页码：788 / 794

页数：7

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