Exploiting the dual reactivity of o-isocyanobenzamide:: Three-component synthesis of 4-imino-4H-3,1-benzoxazines

被引：64
作者：
Bonne, D [1 ]
Dekhane, M
Zhu, JP
机构：
[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France
[2] AstraZeneca PR&D, Macclesfield SK10 2NA, Cheshire, England
来源：
ORGANIC LETTERS | 2005年 / 7卷 / 23期
关键词：
D O I：
10.1021/ol052239w
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A multicomponent synthesis of 4-imino-4H-3,1-benzoxazines is developed. Heating a toluene solution of an aldehyde (6), an amine (7), and an isonitrile (5) in the presence of a stoichiometric amount of ammonium chloride at 60 degrees C for 12 h produces the title compound in good to excellent yields.
引用
收藏
页码：5285 / 5288
页数：4
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