Angiosarcoma of the Pancreas in a Pediatric Patient With an Activating KDR-Internal Tandem Duplication: A Case Report and Review of the Literature

被引：8

作者：

Whitlock, Richard S. ^{[1
,2
]}

Ebare, Kingsley ^{[3
]}

Cheng, Lily S. ^{[1
,2
]}

Fishman, Douglas S. ^{[4
]}

Mills, Joseph L. ^{[5
]}

Nguyen, HaiThuy N. ^{[6
]}

Nuchtern, Jed G. ^{[1
,2
]}

Ruan, Wenly ^{[4
]}

Smith, Valeria E. ^{[7
]}

Patel, Kalyani A. ^{[3
]}

Fisher, Kevin E. ^{[3
]}

Vasudevan, Sanjeev A. ^{[1
,2
]}

机构：

[1] Baylor Coll Med, Texas Childrens Surg Oncol Program, Div Pediat Surg, Michael E DeBakey Dept Surg, Houston, TX 77030 USA

[2] Baylor Coll Med, Duncan L Canc Ctr, Texas Childrens Dept Surg, Houston, TX 77030 USA

[3] Baylor Coll Med, Texas Childrens Hosp, Dept Pathol & Immunol, Houston, TX 77030 USA

[4] Baylor Coll Med, Texas Childrens Hosp, Div Pediat Gastroenterol, Houston, TX 77030 USA

[5] Baylor Coll Med, Texas Childrens Hosp, Singleton Dept Radiol, Houston, TX 77030 USA

[6] Baylor Coll Med, Texas Childrens Hosp, Dept Hematol Oncol, Houston, TX 77030 USA

[7] Baylor Coll Med, Texas Childrens Hosp, Michael E DeBakey Dept Surg, Div Vasc Surg, Houston, TX 77030 USA

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2022年 / 44卷 / 03期

关键词：

pediatric; pancreas; angiosarcoma; resection; VEGFR2; KDR; SOFT-TISSUE; RARE; FEATURES; CHILDREN; TUMORS;

D O I：

10.1097/MPH.0000000000002248

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic angiosarcoma is an exceedingly rare malignancy accounting for <1% of pancreatic neoplasms. A very limited number of pancreatic angiosarcomas have been reported in the literature without any cases described in children. We present the case of a 17-year-old female diagnosed with angiosarcoma of the pancreas following pancreaticoduodenectomy for a pancreatic mass, initially presumed to be a solid pseudopapillary neoplasm of the pancreas. The angiosarcoma was found to have a novel activating internal tandem duplication in the KDR gene (KDR-internal tandem duplication). We discuss the current literature on this disease process. This is the first reported case of pancreatic angiosarcoma in a pediatric patient and the first with an activating KDR-internal tandem duplication.

引用

页码：E751 / E755

页数：5

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