Hypoxia and oxidative stress in breast cancer - Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer

被引：358
作者：
Brown, NS [1 ]
Bicknell, R [1 ]
机构：
[1] Univ Oxford, John Radcliffe Hosp, WIMM, Imperial Canc Res Fund,Mol Angiogenesis Lab, Oxford OX3 9DS, England
来源：
BREAST CANCER RESEARCH | 2001年 / 3卷 / 05期
关键词：
angiogenesis; apoptosis; breast cancer; metastasis; oxidative stress;
D O I：
10.1186/bcr315
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Reactive oxygen species (ROS) damage DNA, but the role of ROS in breast carcinoma may not be limited to the mutagenic activity that drives carcinoma initiation and progression. Carcinoma cells in vitro and in vivo are frequently under persistent oxidative stress. In the present review, we outline potential causes of oxygen radical generation within carcinoma cells and explore the possible impact of oxidative stress on the clinical outcome of breast carcinoma.
引用
收藏
页码：323 / 327
页数：5
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