Selenoproteins in Tumorigenesis and Cancer Progression

被引：85

作者：

Short, Sarah P. ^{[1
]}

Williams, Christopher S. ^{[1
,2
,3
,4
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Nashville, TN 37235 USA

[2] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA

[3] Vanderbilt Univ, Med Ctr, Vanderbilt Ingram Canc Ctr, Nashville, TN 37235 USA

[4] Vet Affairs Tennessee Valley HealthCare Syst, Nashville, TN 37212 USA

来源：

SELENIUM AND SELENOPROTEINS IN CANCER | 2017年 / 136卷

关键词：

SELENOCYSTEINE TRANSFER-RNA; HYDROPEROXIDE GLUTATHIONE-PEROXIDASE; MAMMALIAN THIOREDOXIN REDUCTASE; APOLIPOPROTEIN-E RECEPTOR-2; PREVENTION TRIAL SELECT; SQUAMOUS-CELL CARCINOMA; RENAL PROXIMAL TUBULE; PROSTATE-CANCER; SELENIUM DEFICIENCY; COLORECTAL-CANCER;

D O I：

10.1016/bs.acr.2017.08.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Selenium is a micronutrient essential to human health and has long been associated with cancer prevention. Functionally, these effects are thought to be mediated by a class of selenium-containing proteins known as selenoproteins. Indeed, many selenoproteins have antioxidant activity which can attenuate cancer development by minimizing oxidative insult and resultant DNA damage. However, oxidative stress is increasingly being recognized for its "double-edged sword"effect in tumorigenesis, whereby it can mediate both negative and positive effects on tumor growth depending on the cellular context. In addition to their roles in redox homeostasis, recent work has also implicated selenoproteins in key oncogenic and tumor-suppressive pathways. Together, these data suggest that the overall contribution of selenoproteins to tumorigenesis is complicated and may be affected by a variety of factors. In this review, we discuss what is currently known about selenoproteins in tumorigenesis with a focus on their contextual roles in cancer development, growth, and progression.

引用

页码：49 / 83

页数：35

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