Loneliness and vascular biomarkers: the Dublin Healthy Ageing Study

被引：37

作者：

O'Luanaigh, C. ^{[1
]}

O'Connell, H. ^{[1
]}

Chin, A. V. ^{[1
]}

Hamilton, F. ^{[1
]}

Coen, R. ^{[1
]}

Walsh, C. ^{[1
]}

Walsh, J. B. ^{[1
]}

Coakley, D. ^{[1
]}

Molloy, A. ^{[2
]}

Scott, J. ^{[2
]}

Cunningham, C. J. ^{[1
]}

Lawlor, B. A. ^{[1
]}

机构：

[1] St James Hosp, Mercers Inst Res Ageing, Dublin 8, Ireland

[2] Trinity Coll Dublin, Sch Biochem & Immunol, Dublin 2, Ireland

来源：

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY | 2012年 / 27卷 / 01期

关键词：

HbA1c; loneliness; older people; vascular biomarkers; SOCIAL NETWORKS; ELDERLY-PEOPLE; MORTALITY; SUPPORT; DISEASE; STRESS; RISK; HOMOCYSTEINE; INFLAMMATION; AGE;

D O I：

10.1002/gps.2695

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background Loneliness has been associated with poor physical health and a link has been suggested between the presence of loneliness, cardiovascular health and inflammatory markers. Objective: To investigate the association between vascular disease biomarkers and loneliness in a community-dwelling non-demented elderly population. Design: cross-sectional community based assessment. Participants: 466 subjects with mean age 75.45 (SD, 6.06) years. 208 (44.6%) were male. Results: Higher levels of HbA1c, but not other vascular biomarkers were independently associated with being lonely. Conclusion: Loneliness was associated with raised levels of HbA1c in a community dwelling elderly population. The mechanism for this association has yet to be elucidated but may reflect an abnormal stress response in people who are lonely. Copyright (C) 2011 John Wiley & Sons, Ltd.

引用

页码：83 / 88

页数：6

共 37 条

[1] Day-to-day dynamics of experience-cortisol associations in a population-based sample of older adults [J].

Adam, Emma K. ;

Hawkley, Louise C. ;

Kudielka, Brigitte M. ;

Cacioppo, John T. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (45) :17058-17063

[2]

[Anonymous], 2006, NICE CLIN GUID CG34

[3]

[Anonymous], 2002, STRUCTURED CLIN INTE

[4]

[Anonymous], 1964, MANUAL EYSENCK PERSO, DOI DOI 10.1007/SPRINGERREFERENCE_184643

[5] THE POTENTIAL ROLE OF PSYCHOSOCIAL STRESS ON LEVELS OF HEMOGLOBIN-A1C (HBA1C) AND FASTING PLASMA-GLUCOSE IN ELDERLY PEOPLE [J].

ARNETZ, BB .

JOURNALS OF GERONTOLOGY, 1984, 39 (04) :424-429

[6] Lonely traits and concomitant physiological processes: the MacArthur social neuroscience studies [J].

Cacioppo, JT ;

Ernst, JM ;

Burleson, MH ;

McClintock, MK ;

Malarkey, WB ;

Hawkley, LC ;

Kowalewski, RB ;

Paulsen, A ;

Hobson, JA ;

Hugdahl, K ;

Spiegel, D ;

Berntson, GG .

INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, 2000, 35 (2-3) :143-154

[7] Loneliness and health: Potential mechanisms [J].

Cacioppo, JT ;

Hawkley, LC ;

Crawford, LE ;

Ernst, JM ;

Burleson, MH ;

Kowalewski, RB ;

Malarkey, WB ;

Van Cauter, E ;

Berntson, GG .

PSYCHOSOMATIC MEDICINE, 2002, 64 (03) :407-417

[8] Social regulation of gene expression in human leukocytes [J].

Cole, Steve W. ;

Hawkley, Louise C. ;

Arevalo, Jesusa M. ;

Sung, Caroline Y. ;

Rose, Robert M. ;

Cacioppo, John T. .

GENOME BIOLOGY, 2007, 8 (09)

[9] Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses [J].

Danesh, J ;

Whincup, P ;

Walker, M ;

Lennon, L ;

Thomson, A ;

Appleby, P ;

Gallimore, JR ;

Pepys, MB .

BMJ-BRITISH MEDICAL JOURNAL, 2000, 321 (7255) :199-204

[10]

Eysenck H. J., 1975, Manual of the Eysenck Personality Questionnaire

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