TCL1A gene involvement in T-cell prolymphocytic leukemia in Japanese patients

被引:6
作者
Yokohama, Akihiko [1 ,2 ]
Saitoh, Akio [2 ]
Nakahashi, Hirotaka [2 ]
Mitsui, Takeki [2 ]
Koiso, Hiromi [2 ]
Kim, Yoshitora [3 ]
Uchiumi, Hideki [2 ]
Saitoh, Takayuki [2 ]
Handa, Hiroshi [2 ]
Jimbo, Takahiro [4 ]
Murayama, Kayoko [5 ]
Sakura, Tohru [6 ]
Murakami, Hirokazu [7 ]
Karasawa, Masamitsu [1 ]
Nojima, Yoshihisa [2 ]
Tsukamoto, Norifumi [8 ]
机构
[1] Gunma Univ, Univ Hosp, Fac Med, Blood Transfus Serv, Maebashi, Gunma 3718511, Japan
[2] Gunma Univ, Grad Sch Med, Dept Med & Clin Sci, Maebashi, Gunma 3718511, Japan
[3] Fukaya Red Cross Hosiptal, Dept Internal Med, Fukaya, Saitama, Japan
[4] Fujioka Gen Hosp, Dept Internal Med, Fujioka, Gunma, Japan
[5] Gunma Prefectural Canc Ctr, Dept Hematol, Ota, Gunma, Japan
[6] Saiseikai Maebashi Hosp, Leukemia Res Ctr, Maebashi, Gunma, Japan
[7] Gunma Univ, Sch Hlth Sci, Fac Med, Maebashi, Gunma 3718511, Japan
[8] Gunma Univ, Univ Hosp, Fac Med, Ctr Oncol, Maebashi, Gunma 3718511, Japan
关键词
T-PLL; TCL1; MTCP1; TCL6; TRISOMY; 8Q; EXPRESSION; ABNORMALITIES; VARIANT;
D O I
10.1007/s12185-011-0986-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
T-cell prolymphocytic leukemia (T-PLL) is a rare type of peripheral T-cell leukemia. In this study, we examined the clinical and biological characteristics of 11 Japanese patients with T-PLL. Median age was 74 years, with male predominance. Median lymphocyte frequency was 85.3% in blood. Physical characteristics were splenomegaly (36.4%), tiny lymph adenopathy (63.6%), skin lesion (9.1%) and pleural effusion (27.3%). Median survival was 30.1 months, despite treatment with various chemotherapeutic modalities. Although complex chromosomal abnormalities were observed in 5 of 11 cases (45.5%), typical 14q32 and Xq28 abnormalities were not detected. TCL1A mRNA expression was observed in 6 of 11 cases (54.5%) on real-time quantitative PCR. In 5 of these 6 cases, flow cytometric analysis and/or immunohistochemistry confirmed the expression of TCLA1 protein. Split signals for the TCL1 region on fluorescence in situ hybridization confirmed rearrangement in 3 out of 7 cases evaluated. These cases corresponded to cases that were positive for TCL1A expression, suggesting that rearrangement of the TCL1 region induced high expression of TCL1A gene. In summary, a substantial number of T-PLL cases in Japan had abnormal expression of TCL1A, probably due to rearrangement of TCL1 region. Expression and/or rearrangement of TCL1A may, therefore, be a useful marker for diagnosing T-PLL, regardless of chromosomal abnormalities.
引用
收藏
页码:77 / 85
页数:9
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