Prophylactic donor lymphocyte infusion after allogeneic stem cell transplantation in acute leukaemia - a matched pair analysis by the Acute Leukaemia Working Party of EBMT

被引：90

作者：

Schmid, Christoph ^{[1
]}

Labopin, Myriam ^{[2
,3
]}

Schaap, Nicolaas ^{[4
]}

Veelken, Hendrik ^{[5
]}

Schleuning, Michael ^{[6
]}

Stadler, Michael ^{[7
]}

Finke, Juergen ^{[8
]}

Hurst, Erin ^{[9
]}

Baron, Frederic ^{[10
]}

Ringden, Olle ^{[11
]}

Bug, Gesine ^{[12
]}

Blaise, Didier ^{[13
]}

Tischer, Johanna ^{[14
]}

Bloor, Adrian ^{[15
]}

Esteve, Jordi ^{[16
]}

Giebel, Sebastian ^{[17
,18
]}

Savani, Bipin ^{[19
]}

Gorin, Norbert-Claude ^{[2
,3
]}

Ciceri, Fabio ^{[20
]}

Mohty, Mohamad ^{[2
,3
]}

Nagler, Anton ^{[21
]}

机构：

[1] Univ Munich, Dept Haematol & Oncol, Klinikum Augsburg, Stenglinstr 2, D-86156 Augsburg, Germany

[2] Univ Paris 06, Paris, France

[3] EBMT Data Off, Paris, France

[4] Radboud Univ Nijmegen, Med Ctr, Nijmegen, Netherlands

[5] Leiden Univ Hosp, BMT Ctr Leiden, Leiden, Netherlands

[6] Deutsch Klin Diagnost, KMT Zentrum, Wiesbaden, Germany

[7] Hannover Med Sch, Dept Haematol & Oncol, Hannover, Germany

[8] Univ Freiburg, Dept Med Haematol & Oncol, Freiburg, Germany

[9] NCCN Freeman Hosp, Bone Marrow Transplant Unit, Newcastle Upon Tyne, Tyne & Wear, England

[10] Univ Liege, Dept Med, Div Haematol, Liege, Belgium

[11] Karolinska Univ Hosp Huddinge, Dept Lab Med, Div Therapeut Immunol, Karolinska Inst, Stockholm, Sweden

[12] Univ Klinikum, Dept Med 2, Haematol & Oncol, Frankfurt, Germany

[13] Marseille Inst Paoli Calmettes, Programme Transplantat & Therapie, Cellulaire Ctr Rech Cancerol, Marseille, France

[14] Ludwig Maximilians Univ Munchen, Dept Med 3, Haematol & Oncol, Munich, Germany

[15] Christie NHS Fdn Trust, Stein Cell Transplantat Unit, Manchester, Lancs, England

[16] Hosp Clin Barcelona, IDIBAPS, Dept Haematol, Barcelona, Spain

[17] Maria Sklodowska Curie Canc Ctr, Gliwice, Poland

[18] Inst Oncol, Gliwice Branch, Gliwice, Poland

[19] Vanderbilt Univ Sch Med, Long Term Transplant Clin, Nashville, TN USA

[20] Univ Milan, Dept Haematol, Osp San Raffaele, Milan, Italy

[21] Chaim Sheba Med Ctr, Tel Hashomer, Israel

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2019年 / 184卷 / 05期

关键词：

acute leukaemia; allogeneic stem cell transplantation; DLI; relapse prevention; ACUTE MYELOID-LEUKEMIA; STAGE ACUTE-LEUKEMIA; SURVIVAL; PREVENTION; ANTIGEN;

D O I：

10.1111/bjh.15691

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Strategies for relapse prevention after allogeneic transplantation in acute leukaemia are warranted. A registry-based matched-pair analysis evaluated the efficacy of prophylactic donor lymphocyte infusion (proDLI). Adults receiving proDLI in complete remission (CR) and controls were pair-matched for age, diagnosis, cytogenetics, stage, donor, gender, conditioning and T-cell depletion. Eighty-nine pairs were identified (median follow-up: 6.9 years). Within the entire cohort, no difference was observed. However, among patients with high-risk acute myeloid leukaemia (AML) (unfavourable cytogenetics and/or transplanted beyond first CR), proDLI recipients had improved overall survival (69.8% vs. 40.2% in controls, P = 0.027). ProDLI has moderate efficacy, but can contribute to improved outcome in high-risk AML.

引用

页码：782 / 787

页数：6

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