Organocatalytic asymmetric chlorinative dearomatization of naphthols

被引：105
作者：
Yin, Qin [1 ]
Wang, Shou-Guo [1 ]
Liang, Xiao-Wei [1 ]
Gao, De-Wei [1 ]
Zheng, Jun [1 ]
You, Shu-Li [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
CHEMICAL SCIENCE | 2015年 / 6卷 / 07期
基金：
中国国家自然科学基金;
关键词：
ENANTIOSELECTIVE SYNTHESIS; OXIDATIVE DEAROMATIZATION; ALLYLIC DEAROMATIZATION; PHENOL DEAROMATIZATION; MICHAEL REACTION; DESYMMETRIZATION; CYCLOHEXADIENONES; SPIROLACTONIZATION; CHLOROCYCLIZATION; CONSTRUCTION;
D O I：
10.1039/c5sc00494b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An organocatalytic asymmetric chlorinative dearomatization of naphthols was realized for the first time, providing chiral naphthalenones with a Cl-containing all-substituted stereocenter in excellent yields and enantioselectivity (up to 97% yield and 96% ee). The reaction features mild reaction conditions, good tolerance of diverse functional groups and simple reaction operation.
引用
收藏
页码：4179 / 4183
页数：5
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