Cytotoxic butenolides and diphenyl ethers from the endophytic fungus Pestalotiopsis sp.

被引：11

作者：

Yang, Beiye ^{[1
]}

Tong, Qingyi ^{[1
]}

Lin, Shuang ^{[1
]}

Guo, Jieru ^{[2
]}

Zhang, Jinwen ^{[2
]}

Liu, Junjun ^{[1
]}

Wang, Jianping ^{[1
]}

Zhu, Hucheng ^{[1
]}

Hu, Zhengxi ^{[1
]}

Zhang, Yonghui ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2019年 / 29卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Pestalotiopsis sp; Butenolides; Diphenyl ethers; Cytotoxic activity; METABOLITES; DERIVATIVES;

D O I：

10.1016/j.phytol.2018.11.021

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chemical investigation of the plant endophytic fungus Pestalotiopsis sp. afforded two new butenolides, pestalolides B and C (1 and 2), two new diphenyl ethers, pestalotethers E and F (3 and 4), together with seven known compounds (5-11). Their structures were established by extensive spectroscopic analyses and the absolute configuration of 1 was further confirmed by ECD calculation. Structurally, compound 1 represents the first example of a new type of butenolide derivatives, bearing an unprecedented carbon scaffold having 13 carbon atoms. Compounds 1-4 were evaluated for the cytotoxic activities, and compound 1 showed remarkable inhibitory potency against human tumor HL60, U87MG, MDA-MB-231, and HEP-3B cell lines, with IC50, values of 1.42, 5.90, 5.90, and 4.29 mu M, respectively.

引用

收藏

页码：186 / 189

页数：4

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