Ultrasensitive Detection of Aqueous Uranyl Based on Uranyl-Triggered Protein Photocleavage

被引：57

作者：

Feng, Tiantian ^{[1
]}

Yuan, Yihui ^{[1
]}

Zhao, Shilei ^{[1
]}

Feng, Lijuan ^{[1
]}

Yan, Bingjie ^{[1
]}

Cao, Meng ^{[1
]}

Zhang, Jiacheng ^{[1
]}

Sun, Wenyan ^{[1
]}

Lin, Ke ^{[1
]}

Wang, Ning ^{[1
]}

机构：

[1] Hainan Univ, State Key Lab Marine Resource Utilizat South Chin, Haikou 570228, Hainan, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2022年 / 61卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Photocleavage; Proteins; Selectivity; Sensitivity; Uranyl Detection; URANIUM; FLUORESCENT; IONS; NANOPARTICLES; DNAZYME; ENERGY; PROBE; FABRICATION; STABILITY; SENSORS;

D O I：

10.1002/anie.202115886

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The detection of environmental uranyl is attracting increasing attention. However, the available detection strategies mainly depend on the selective recognition of uranyl, which is subject to severe interference by coexisting metal ions. Herein, based on the unique uranyl-triggered photocleavage property, the protein BSA is labelled with fluorescent molecules that exhibit an aggregation-induced emission effect for uranyl detection. Uranyl-triggered photocleavage causes the separation of the fluorescent-molecule-labelled protein fragments, leading to attenuation of the emission fluorescence, which is used as a signal for uranyl detection. This detection strategy shows high selectivity for uranyl and an ultralow detection limit of 24 pM with a broad detection range covering five orders of magnitude. The detection method also shows high reliability and stability, making it a promising technique for practical applications in diverse environments.

引用

页数：7

共 65 条

[1] Design Strategies to Enhance Amidoxime Chelators for Uranium Recovery [J].

Aguila, Briana ;

Sun, Qi ;

Cassady, Harper ;

Abney, Carter W. ;

Li, Baiyan ;

Mai, Shengqian .

ACS APPLIED MATERIALS & INTERFACES, 2019, 11 (34) :30919-30926

[2] AIE based fluorescent self assembled glycoacrylamides for E.coli detection and cell imaging [J].

Ajish, Juby K. ;

Kumar, K. S. Ajish ;

Ruhela, Aakanksha ;

Subramanian, Mahesh ;

Ballal, Anand Damodar ;

Kumar, Manmohan .

SENSORS AND ACTUATORS B-CHEMICAL, 2018, 255 :1726-1734

[3] AIE-based luminescence probes for metal ion detection [J].

Alam, Parvej ;

Leung, Nelson L. C. ;

Zhang, Jing ;

Kwok, Ryan T. K. ;

Lam, Jacky W. Y. ;

Tang, Ben Zhong .

COORDINATION CHEMISTRY REVIEWS, 2021, 429

[4]

Brugge Doug, 2005, Reviews on Environmental Health, V20, P177

[5] Investigation of the effects of copper ions on protein aggregation using a model system [J].

Capanni, C ;

Taddei, N ;

Gabrielli, S ;

Messori, L ;

Orioli, P ;

Chiti, F ;

Stefani, M ;

Ramponi, G .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2004, 61 (7-8) :982-991

[6] Metal ion as both a cofactor and a probe of metal-binding sites in a uranyl-specific DNAzyme: a uranyl photocleavage study [J].

Cepeda-Plaza, Marjorie ;

Null, Eric L. ;

Lu, Yi .

NUCLEIC ACIDS RESEARCH, 2013, 41 (20) :9361-9370

[7] Influence of NaCl on optical properties, large-strain rheology and water holding capacity of heat-induced whey protein isolate gels [J].

Chantrapornchai, W ;

McClements, DJ .

FOOD HYDROCOLLOIDS, 2002, 16 (05) :467-476

[8] Structural Modification Orientated Multifunctional AIE Fluorescence Probes: Organelles Imaging and Effective Photosensitizer for Photodynamic Therapy [J].

Chen, Kongqi ;

Zhang, Rongyuan ;

Wang, Zhiming ;

Zhang, Weijie ;

Tang, Ben Zhong .

ADVANCED OPTICAL MATERIALS, 2020, 8 (02)

[9] A responsive photonic crystal film sensor for the ultrasensitive detection of uranyl ions [J].

Chen, Qianshan ;

Wang, Changping ;

Wang, Shihong ;

Zhou, Jun ;

Wu, Zhaoyang .

ANALYST, 2020, 145 (16) :5624-5630

[10] Opportunities and challenges for a sustainable energy future [J].

Chu, Steven ;

Majumdar, Arun .

NATURE, 2012, 488 (7411) :294-303

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