Curcumin regulates the homeostasis of Th17/Treg and improves the composition of gut microbiota in type 2 diabetic mice with colitis

被引:32
作者
Xiao, Qiu-Ping [1 ,2 ]
Zhong, You-Bao [1 ,3 ]
Kang, Zeng-Ping [4 ]
Huang, Jia-Qi [4 ]
Fang, Wei-Yan [4 ]
Wei, Si-Yi [4 ]
Long, Jian [4 ]
Li, Shan-Shan [1 ]
Zhao, Hai-Mei [5 ]
Liu, Duan-Yong [6 ]
机构
[1] Jiangxi Univ Tradit Chinese Med, Lab Anim Res Ctr Sci & Technol, Nanchang, Jiangxi, Peoples R China
[2] Jiangzhong Pharmaceut Co Ltd, Res & Dev Dept, Nanchang, Jiangxi, Peoples R China
[3] Jiangxi Univ Tradit Chinese Med, Key Lab Anim Model TCM Syndromes Depress, Nanchang, Jiangxi, Peoples R China
[4] Jiangxi Univ Tradit Chinese Med, Coll Tradit Chinese Med, Nanchang, Jiangxi, Peoples R China
[5] Jiangxi Univ Tradit Chinese Med, Dept Postgrad, Nanchang, Jiangxi, Peoples R China
[6] Jiangxi Univ Tradit Chinese Med, Formula Pattern Res Ctr, Nanchang, Jiangxi, Peoples R China
基金
中国国家自然科学基金;
关键词
colitis; curcumin; intestinal microbiota; Th17; Treg; type 2 diabetes mellitus; INFLAMMATORY-BOWEL-DISEASE; DB/DB MOUSE MODEL; ULCERATIVE-COLITIS; TH17; CELLS; MELLITUS; PHARMACOLOGY; POPULATION; DIVERSITY; SEVERITY; INSIGHTS;
D O I
10.1002/ptr.7404
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Diabetes mellitus (DM) is one of the most common complications in patients with ulcerative colitis (UC). Curcumin has a wide range of bioactive and pharmacological properties and is commonly used as an adjunct to the treatment of UC and DM. However, the role of curcumin in UC complicated by DM has not been elucidated. Therefore, this study was conducted to construct a model of UC complicating diabetes by inducing UC in DB mice (spontaneously diabetic) with dextran sodium sulfate. In this study, curcumin (100 mg/kg/day) significantly improved the symptoms of diabetes complicated by UC, with a lower insulin level, heavier weight, longer and lighter colons, fewer mucosal ulcers and less inflammatory cell infiltration. Moreover, compared to untreated DB mice with colitis, curcumin-treated mice showed weaker Th17 responses and stronger Treg responses. In addition, curcumin regulated the diversity and relative abundance of intestinal microbiota in mice with UC complicated by DM at the phylum, class, order, family and genus levels. Collectively, curcumin effectively alleviated colitis in mice with type 2 diabetes mellitus by restoring the homeostasis of Th17/Treg and improving the composition of the intestinal microbiota
引用
收藏
页码:1708 / 1723
页数:16
相关论文
共 50 条
  • [41] IL-21 regulates experimental colitis by modulating the balance between Treg and Th17 cells
    Fantini, Massimo C.
    Rizzo, Agelamaria
    Final, Daniele
    Caruso, Roberta
    Becker, Christoph
    Neurath, Markus F.
    MacDonald, Thomas T.
    Pallone, Francesco
    Monteleone, Giovanni
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2007, 37 (11) : 3155 - 3163
  • [42] Baitouweng Decoction Ameliorates Ulcerative Colitis in Mice Partially Attributed to Regulating Th17/Treg Balance and Restoring Intestinal Epithelial Barrier
    Miao, Zhiwei
    Chen, Liping
    Feng, Hui
    Gu, Mingjia
    Yan, Jing
    Xu, Yi
    Ye, Bai
    FRONTIERS IN PHARMACOLOGY, 2021, 11
  • [43] Adherent-invasive Escherichia coli LF82 aggravated intestinal inflammation in colitis mice by affecting the gut microbiota and Th17/Treg cell differentiation balance
    Sumei Sha
    Hong Zeng
    Huijun Gao
    Haitao Shi
    Xiaojing Quan
    Fenrong Chen
    Meng Liu
    Bin Xu
    Xin Liu
    Archives of Microbiology, 2023, 205
  • [44] Selective activation of cannabinoid receptor 2 regulates Treg/Th17 balance to ameliorate neutrophilic asthma in mice
    Wei, Chaochao
    Huang, Linhui
    Zheng, Yamei
    Cai, Xingjun
    ANNALS OF TRANSLATIONAL MEDICINE, 2021, 9 (12)
  • [45] Adherent-invasive Escherichia coli LF82 aggravated intestinal inflammation in colitis mice by affecting the gut microbiota and Th17/Treg cell differentiation balance
    Sha, Sumei
    Zeng, Hong
    Gao, Huijun
    Shi, Haitao
    Quan, Xiaojing
    Chen, Fenrong
    Liu, Meng
    Xu, Bin
    Liu, Xin
    ARCHIVES OF MICROBIOLOGY, 2023, 205 (06)
  • [46] Lactobacillus casei regulates differentiation of Th17/Treg cells to reduce intestinal inflammation in mice
    Wang, Kai
    Dong, Hao
    Qi, Yu
    Pei, Zhihua
    Yi, Shushuai
    Yang, Xiaojie
    Zhao, Yanli
    Meng, Fanxing
    Yu, Shouping
    Zhou, Tiezhong
    Hu, Guixue
    CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE, 2017, 81 (02): : 122 - 128
  • [47] Acupuncture regulates the Th17/Treg balance and improves cognitive deficits in a rat model of vascular dementia
    Liu Qiuping
    Pan Pan
    Ling Zhenzhen
    Zhang Zhen
    Zhang Xuezhu
    Li Shuting
    HELIYON, 2023, 9 (02)
  • [48] SDH, a novel diarylheptane compound, alleviates dextran sulfate sodium (DSS)-induced colitis by reducing Th1/Th2/Th17 induction and regulating the gut microbiota in mice
    Yang, Fei
    Zhang, Minjie
    Xu, Ruyi
    Yu, Yunhui
    Feng, Haimei
    Li, Dong
    Li, Ling
    Zhang, Biyan
    Liu, Gang
    Wang, Yanping
    Xie, Qing
    Chen, Zijun
    Cao, Yu
    Li, Yunsen
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2024, 134
  • [49] Lactobacillus paracasei R3 protects against dextran sulfate sodium (DSS)-induced colitis in mice via regulating Th17/Treg cell balance
    Huang, Juan
    Yang, Ziyan
    Li, Yanyun
    Chai, Xingxing
    Liang, Yanfang
    Lin, Bihua
    Ye, Ziyu
    Zhang, Shaobing
    Che, Zhengping
    Zhang, Hailiang
    Zhang, Xueying
    Zhang, Zhao
    Chen, Tao
    Yang, Weiqing
    Zeng, Jincheng
    JOURNAL OF TRANSLATIONAL MEDICINE, 2021, 19 (01)
  • [50] Resveratrol modulates the gut microbiota to prevent murine colitis development through induction of Tregs and suppression of Th17 cells
    Alrafas, Haider Rasheed
    Busbee, Philip B.
    Nagarkatti, Mitzi
    Nagarkatti, Prakash S.
    JOURNAL OF LEUKOCYTE BIOLOGY, 2019, 106 (02) : 467 - 480