Strongylophorines, meroditerpenoids from the marine sponge Petrosia corticata, function as proteasome inhibitors

被引：24

作者：

Noda, Ai ^{[1
]}

Sakai, Eriko ^{[1
]}

Kato, Hikaru ^{[1
]}

Losung, Fitje ^{[2
]}

Mangindaan, Remy E. P. ^{[2
]}

de Voogd, Nicole J. ^{[3
]}

Yokosawa, Hideyoshi ^{[4
]}

Tsukamoto, Sachiko ^{[1
]}

机构：

[1] Kumamoto Univ, Grad Sch Pharmaceut Sci, Dept Nat Med, Kumamoto 8620973, Japan

[2] Sam Ratulangi Univ, Fac Fisheries & Marine Sci, Manado 95115, Indonesia

[3] Nat Biodivers Ctr, NL-2300 RA Leiden, Netherlands

[4] Aichi Gakuin Univ, Sch Pharm, Chikusa Ku, Nagoya, Aichi 4648650, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 13期

关键词：

Strongylophorine; Meroditerpenoid; Petrosia corticata; Proteasome inhibitor; ACANTHOSTRONGYLOPHORA-INGENS; DRUG TARGETS; DURISSIMA; CANCER; SYSTEM;

D O I：

10.1016/j.bmcl.2015.04.075

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new strongylophorine derivatives, along with six known strongylophorines, were isolated from the marine sponge Petrosia corticata as proteasome inhibitors. Of these, a hemiacetal mixture of strongylophorines-13/-14 was the strongest inhibitor of the proteasome with an IC50 of 2.1 mu M. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：2650 / 2653

页数：4

共 12 条

[1] Potential for proteasome inhibition in the treatment of cancer
Adams, J
[J]. DRUG DISCOVERY TODAY, 2003, 8 (07) : 307 - 315
[2] Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets
Bedford, Lynn
Lowe, James
Dick, Lawrence R.
Mayer, R. John
Brownell, James E.
[J]. NATURE REVIEWS DRUG DISCOVERY, 2011, 10 (01) : 29 - 46
[3] BRAEKMAN JC, 1978, B SOC CHIM BELG, V87, P917
[4] Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?
Cohen, Philip
Tcherpakov, Marianna
[J]. CELL, 2010, 143 (05) : 686 - 693
[5] Acantholactam and Pre-neo-kauluamine, Manzamine-Related Alkaloids from the Indonesian Marine Sponge Acanthostrongylophora ingens
El-Desoky, Ahmed H.
Kato, Hikaru
Eguchi, Keisuke
Kawabata, Tetsuro
Fujiwara, Yukio
Losung, Fitje
Mangindaan, Remy E. P.
de Voogd, Nicole J.
Takeya, Motohiro
Yokosawa, Hideyoshi
Tsukamoto, Sachiko
[J]. JOURNAL OF NATURAL PRODUCTS, 2014, 77 (06): : 1536 - 1540
[6] Acanthomanzamines A-E with New Manzamine Frameworks from the Marine Sponge Acanthostrongylophora ingens
Furusato, Akane
Kato, Hikaru
Nehira, Tatsuo
Eguchi, Keisuke
Kawabata, Tetsuro
Fujiwara, Yukio
Losung, Fitje
Mangindaan, Remy E. P.
de Voogd, Nicole J.
Takeya, Motohiro
Yokosawa, Hideyoshi
Tsukamoto, Sachiko
[J]. ORGANIC LETTERS, 2014, 16 (15) : 3888 - 3891
[7] New strongylophorines from the okinawan marine sponge Petrosia (Strongylophora) corticata
Hoshino, A
Mitome, H
Miyaoka, H
Shintani, A
Yamada, Y
van Soest, RWM
[J]. JOURNAL OF NATURAL PRODUCTS, 2003, 66 (12): : 1600 - 1605
[8] Seven new meroditerpenoids, from the marine sponge Strongylophora strongylata, that inhibited the maturation of starfish oocytes
Liu, HW
Namikoshi, M
Akano, K
Kobayashi, H
Nagai, H
Yao, XS
[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2005, 7 (04) : 661 - 670
[9] Targeting the ubiquitin pathway for cancer treatment
Liu, Jia
Shaik, Shavali
Dai, Xiangpeng
Wu, Qiong
Zhou, Xiuxia
Wang, Zhiwei
Wei, Wenyi
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2015, 1855 (01): : 50 - 60
[10] METABOLITES OF THE SPONGE STRONGYLOPHORA-DURISSIMA FROM MARICABAN ISLAND, PHILIPPINES
SALVA, J
FAULKNER, DJ
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (06) : 1941 - 1943

← 1 2 →