Immunometabolism in atherosclerosis: Investigating cholesterol crystals as potent drivers of metabolic reprogramming and M1 macrophage polarisation

被引：0
|
作者：
Rourke, Sinead A. O. [1 ]
Neto, Nuno G. [1 ]
Devilly, Eimear [3 ]
Shanley, Lianne C. [1 ]
Dunne, Aisling [3 ]
Monaghan, Michael G. [2 ]
机构：
[1] Trinity Coll Dublin, Trinity Ctr Biomed Engn, Dublin, Ireland
[2] Trinity Coll Dublin, Sch Engn, Dept Mech Mfg & Biomed Engn, Dublin, Ireland
[3] Trinity Coll Dublin, Sch Biochem & Immunol, Mol Immunol Grp, Dublin, Ireland
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2021年 / 51卷
关键词：
Cardiovascular diseases; immune regulation and therapy; inflammatory disease; macrophage; metabolic control of immune responses;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
P-0283
引用
收藏
页码：212 / 212
页数：1
相关论文
共 14 条
  • [1] M1/M2 macrophage-targeted nanotechnology and PROTAC for the treatment of atherosclerosis
    Ma, Yupeng
    Yang, Xiaofan
    Ning, Ke
    Guo, Haidong
    LIFE SCIENCES, 2024, 352
  • [2] A novel role for the ROS-ATM-Chk2 axis mediated metabolic and cell cycle reprogramming in the M1 macrophage polarization
    Li, Chunlu
    Deng, Chengsi
    Wang, Siwei
    Dong, Xiang
    Dai, Bing
    Guo, Wendong
    Guo, Qiqiang
    Feng, Yanling
    Xu, Hongde
    Song, Xiaoyu
    Cao, Liu
    REDOX BIOLOGY, 2024, 70
  • [3] Irgm1 promotes M1 but not M2 macrophage polarization in atherosclerosis pathogenesis and development
    Fang, Shaohong
    Xu, Yanwen
    Zhang, Yun
    Tian, Jiangtian
    Li, Ji
    Li, Zhaoying
    He, Zhongze
    Chai, Ruikai
    Liu, Fang
    Zhang, Tongshuai
    Yang, Shuang
    Pei, Chunying
    Liu, Xinxin
    Lin, Peng
    Xu, Hongwei
    Yu, Bo
    Li, Hulun
    Sun, Bo
    ATHEROSCLEROSIS, 2016, 251 : 282 - 290
  • [4] Emergence of New Immunopathogenic Factors in Human Yellow Fever: Polarisation of the M1/M2 Macrophage Response in the Renal Parenchyma
    Melo, Juliana Marinho
    Falcao, Luiz Fabio Magno
    da Ponte, Lucas Coutinho Tuma
    Silva, Camilla Costa
    Martins, Livia Caricio
    Chiang, Jannifer Oliveira
    Martins Filho, Arnaldo Jorge
    Franco, Edna Cristina Santos
    Duarte, Maria Irma Seixas
    de Sousa, Jorge Rodrigues
    Vasconcelos, Pedro Fernando da Costa
    Quaresma, Juarez Antonio Simoes
    VIRUSES-BASEL, 2022, 14 (08):
  • [5] M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages
    Gunassekaran, Gowri Rangaswamy
    Vadevoo, Sri Murugan Poongkavithai
    Baek, Moon-Chang
    Lee, Byungheon
    BIOMATERIALS, 2021, 278
  • [6] Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages to Sustain Cell Viability and Pro-Inflammatory Activity
    Wang, Feilong
    Zhang, Song
    Jeon, Ryounghoon
    Vuckovic, Ivan
    Jiang, Xintong
    Lerman, Amir
    Folmes, Clifford D.
    Dzeja, Petras D.
    Herrmann, Joerg
    EBIOMEDICINE, 2018, 30 : 303 - 316
  • [7] Maternal hypercholesterolemia exacerbates atherosclerosis lesions in female offspring through potentiating macrophage polarization toward an inflammatory M1 phenotype
    Chen, Sin-Yu
    Chen, Yi-Zhen
    Lee, Yi-Jing
    Jiang, Chung-Lin
    Lu, Shao-Chun
    Lin, Fu-Jung
    JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2021, 90
  • [8] Naringenin ameliorates skin inflammation and accelerates phenotypic reprogramming from M1 to M2 macrophage polarization in atopic dermatitis NC/Nga mouse model
    Karuppagounder, Vengadeshprabhu
    Arumugam, Somasundaram
    Thandavarayan, Rajarajan Amirthalingam
    Sreedhar, Remya
    Giridharan, Vijayasree V.
    Pitchaimani, Vigneshwaran
    Afrin, Rejina
    Harima, Meilei
    Krishnamurthy, Prasanna
    Suzuki, Kenji
    Nakamura, Masahiko
    Ueno, Kazuyuki
    Watanabe, Kenichi
    EXPERIMENTAL DERMATOLOGY, 2016, 25 (05) : 404 - 407
  • [9] Ergothioneine attenuates psoriasis symptoms through modulation of M1/M2 macrophage polarisation via the NF-κB/JAK-STAT3 pathway
    Li, Ang
    Liu, Yanjie
    Yu, Peiling
    Zhang, Zhiyuan
    Huang, Tengxiao
    Li, Hang
    Wu, Songzhi
    Rong, Xiaoyu
    Liao, Wensheng
    Wang, Hongqiang
    Gao, Yanzheng
    FRONTIERS IN PHARMACOLOGY, 2025, 16
  • [10] Decreased M1 macrophage polarization in dabigatran-treated Ldlr-deficient mice: Implications for atherosclerosis and adipose tissue inflammation
    Feldmann, Kathrin
    Grandoch, Maria
    Kohlmorgen, Christina
    Valentin, Birte
    Gerfer, Stephen
    Nagy, Nadine
    Hartwig, Sonja
    Lehr, Stefan
    Fender, Anke C.
    Fischer, Jens W.
    ATHEROSCLEROSIS, 2019, 287 : 81 - 88
12