Serum Neurofilament Light Chain Levels May Be a Marker of Lower Motor Neuron Damage in Amyotrophic Lateral Sclerosis

被引:3
作者
Zhang, Linjing [1 ,2 ]
Ji, Tuo [1 ,3 ]
Wu, Chujun [1 ,4 ]
Zhang, Shuo [1 ,2 ]
Tang, Lu [1 ,2 ]
Zhang, Nan [1 ,2 ]
Liu, Xiangyi [1 ,2 ]
Fan, Dongsheng [1 ,2 ,5 ]
机构
[1] Peking Univ Third Hosp, Dept Neurol, Beijing, Peoples R China
[2] Beijing Municipal Key Lab Biomarker & Translat Re, Beijing, Peoples R China
[3] Zhengzhou Univ, Affiliated Hosp 1, Dept Neurol, Zhengzhou, Peoples R China
[4] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China
[5] Peking Univ, Minist Educ, Natl Hlth Commiss, Key Lab Neurosci, Beijing, Peoples R China
来源
FRONTIERS IN NEUROLOGY | 2022年 / 13卷
基金
中国国家自然科学基金;
关键词
NfL; amyotrophic lateral sclerosis; axonal degeneration; CMAPs; EMG; electromyogram; DIAGNOSIS; BIOMARKER; SURVIVAL; PROTEINS;
D O I
10.3389/fneur.2022.833507
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objectives The aims of this study were to investigate whether serum neurofilament light chain (NfL) levels were correlated with the severity of the axonal degeneration of lower motor neurons (LMNs) in the early symptomatic phase of amyotrophic lateral sclerosis (ALS). Methods In this prospective study, the serum samples used for NfL measurement were obtained from 103 sporadic ALS outpatients within 2 years of disease duration. The severity of axonal degeneration was assessed by assessing the decrease in the compound muscle action potentials (CMAPs) within a 1-month interval from serum sampling. Results The NfL levels showed a significant positive correlation with the relative score as a proxy for the axonal damage of LMNs in patients with ALS (coefficient: 0.264, p = 0.009). Furthermore, this correlation became stronger (coefficient: 0.582, p = 0.037) when estimated only among patients with disease subtypes that involve only LMNs, that is, patients with flail arm or leg syndrome (FAS or FLS). The levels of NfL increased with the severity of axonal damage of LMNs (F = 6.694, P = 0.0001). Conclusions Serum NfL levels mirrored the severity of the axonal degeneration of LMNs, particularly in patients with signs of predominant LMN involvement. These results may have a profound effect on the selection of patients and the monitoring of treatment efficacy in future disease-modifying clinical trials.
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页数:8
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