IL-7 is critical for homeostatic proliferation and survival of naive T cells

被引：794

作者：

Tan, JT

Dudl, E

LeRoy, E

Murray, R

Sprent, J

Weinberg, KI

Surh, CD ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

[2] Univ So Calif, Childrens Hosp, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90027 USA

[3] Univ So Calif, Childrens Hosp, Keck Sch Med, Dept Pediat, Los Angeles, CA 90027 USA

[4] Eos Biotechnol, San Francisco, CA 94080 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2001年 / 98卷 / 15期

关键词：

D O I：

10.1073/pnas.161126098

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In T cell-deficient conditions, naive T cells undergo spontaneous "homeostatic" proliferation in response to contact with self-MHC/ peptide ligands. With the aid of an in vitro system, we show here that homeostatic proliferation is also cytokine-dependent. The cytokines IL-4, IL-7, and IL-15 enhanced homeostatic proliferation of naive T cells in vitro. Of these cytokines, only IL-7 was found to be critical; thus, naive T cells underwent homeostatic proliferation in IL-4(-) and IL-15(-) hosts but proliferated minimally in IL-7(-) hosts. In addition to homeostatic proliferation, the prolonged survival of naive T cells requires IL-7. Thus, naive T cells disappeared gradually over a 1-month period upon adoptive transfer into IL-7(-) hosts. These findings indicate that naive T cells depend on IL-7 for survival and homeostatic proliferation.

引用

页码：8732 / 8737

页数：6

共 57 条

[1] Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice [J].