The dead phosphatases society: a review of the emerging roles of pseudophosphatases

被引：22

作者：

Reiterer, Veronika ^{[1
]}

Pawlowski, Krzysztof ^{[2
]}

Desrochers, Guillaume ^{[3
,4
]}

Pause, Arnim ^{[3
,4
]}

Sharpe, Hayley J. ^{[5
]}

Farhan, Hesso ^{[1
]}

机构：

[1] Univ Oslo, Inst Basic Med Sci, Oslo, Norway

[2] Warsaw Univ Life Sci SGGW, Inst Biol, Warsaw, Poland

[3] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada

[4] McGill Univ, Goodman Canc Res Ctr, Montreal, PQ, Canada

[5] Babraham Inst, Signalling Programme, Cambridge, England

来源：

FEBS JOURNAL | 2020年 / 287卷 / 19期

基金：

加拿大健康研究院; 英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

dephosphorylation; phosphatase; pseudoenzymes; pseudophosphatase; PROTEIN-TYROSINE-PHOSPHATASE; TUMOR-SUPPRESSOR; REDOX REGULATION; PHOSPHATIDYLINOSITOL PHOSPHATASE; TRANSMEMBRANE PROTEIN; SUBSTRATE RECRUITMENT; TARGETED DISRUPTION; MOLECULAR-CLONING; CRYSTAL-STRUCTURE; CATALYTIC DOMAIN;

D O I：

10.1111/febs.15431

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphatases are a diverse family of enzymes, comprising at least 10 distinct protein folds. Like most other enzyme families, many have sequence variations that predict an impairment or loss of catalytic activity classifying them as pseudophosphatases. Research on pseudoenzymes is an emerging area of interest, with new biological functions repurposed from catalytically active relatives. Here, we provide an overview of the pseudophosphatases identified to date in all major phosphatase families. We will highlight the degeneration of the various catalytic sequence motifs and discuss the challenges associated with the experimental determination of catalytic inactivity. We will also summarize the role of pseudophosphatases in various diseases and discuss the major challenges and future directions in this field.

引用

收藏

页码：4198 / 4220

页数：23

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